A pill that contains four different medicines and is designed to be taken daily could dramatically reduce the number of heart attacks and strokes, a new study has found. The polypill – which is the generic term used to describe a medication that contains multiple active pharmaceutical ingredients – contains aspirin, a cholesterol-lowering statin and two drugs to reduce blood pressure. For the study, researchers from Iran and the UK studied around 6,800 people from more than 100 villages in Iran. Half were given the polypill and advice on how to improve their health through lifestyle changes and the other half were just given the lifestyle changes advice. After five years, the group taking the polypill had experienced 202 cardiovascular events, while the group that had just been given the advice had experienced 301 cardiovascular events. In other words, the group taking the polypill had experienced around a third less cardiovascular events. The researchers say the pill costs just pennies a day, but could have a huge impact, especially in poorer countries where doctors have fewer options available to them. Stroke and coronary heart disease are the top two causes of death worldwide, killing more than 15 million people each year. Obesity, smoking and doing little exercise are all risk factors associated with an unhealthy heart. Based on the findings of the study, if 35 people were all given the polypill daily, it would prevent one of them developing a major heart problem within 5 years. “Given the polypill's affordability, there is considerable potential to improve cardiovascular health and to prevent the world's leading cause of death,” said Dr Nizal Sarrafzadegan, of Isfahan University of Medical Sciences, Iran. The findings of the research are published in The Lancet.