A compound found only in avocados could help reduce type 2 diabetes, new research suggests. The study by researchers from the University of Guelph in Canada found that a fat molecule called avocatin B, or AvoB - which avocados alone contain – can help strengthen insulin sensitivity and could forestall type 2 diabetes. Initial tests involving mice showed that AvoB slowed weight gain and increased insulin sensitivity by ensuring the complete oxidation of fats. As a result, mice that were given the compound had improved glucose tolerance and utilization. Then, in a separate, double-blind placebo‐controlled human trial, an AvoB supplement was given to people with an average Western diet for 60 days. The researchers found that the participants had tolerated the compound well and no negative effects in the liver, muscles, or kidneys were witnessed. There was also some weight loss among participants that took the supplement, though the authors of the study considered it statistically insignificant. Paul Spagnuolo, Ph.D., an associate professor at the University of Guelph, said the research team will now design clinical trials to assess AvoB's effectiveness in people. Furthermore, they have already received clearance from Health Canada to sell AvoB in powder and pill forms, perhaps as early as next year.
Type 2 diabetes is a chronic condition that occurs when a person’s body ineffectively uses insulin. It is the most common form of diabetes, accounting for 90% to 95% of the more than 30 million diabetes cases in America today. Despite rising numbers, it is estimated that around 80% of new type 2 diabetes diagnoses could be prevented with lifestyle changes and more education. But while it’s been known for some time that when added to a genetic predisposition, factors like being overweight and a lack of physical activity increase a person’s risk of developing type 2 diabetes, very little research has been done to determine the impact of other environmental factors. That’s why a new study by a team from the University of Illinois at Chicago (UIC) School of Public Health which set out to determine if type 2 diabetes risk changes between urban and rural environments is interesting. According to the research - which involved examining 3,134 people across the United States - the quality of the air, water, and land, as well as numerous sociodemographic factors, such as education, average household income, violent crime rates, or property crime rates has an impact on a person’s type 2 diabetes risk. So-called ‘built domain factors’ were also used. These included how many fast-food restaurants were in a particular area; how many fatal accidents occurred, and how many highways, roadways, or public housing units there were. The research found that a poorer environmental quality was linked with a higher prevalence of type 2 diabetes. Specifically, inferior air quality and built and sociodemographic factors were associated with a higher risk of diabetes in rural areas, while in urban areas, only air and sociodemographic factors were associated with diabetes risk. “There might be something happening in rural areas that is different than in urban areas. Our findings suggest that environmental exposures may be a bigger factor in rural counties than in urban areas in the U.S.,” explains Dr. Jyotsna Jagai, lead author.
Obesity is worryingly common across the world today. World Health Organization statistics from 2018 show that global obesity has almost tripled since 1975 and most of the world’s population now live in a country where being overweight or obese kills more people than being underweight. But while obesity is known to increase a person’s risk of certain health conditions, new research has revealed that it does not seemingly affect men and women in the same way. According to the study from Oxford University in the United Kingdom, the findings of which are summarized in the journal PLOS Genetics, the risks of developing different health problems as a result of being obese are different for men and women. For example, obese women are at higher risk of developing type-2 diabetes than men. Meanwhile, obese men have a higher risk of chronic kidney disease and chronic obstructive pulmonary disease. The team says their findings add to the existing evidence that preventing and treating obesity is a crucial step in countering the emergence of other health conditions. “This study shows just how harmful carrying excess weight can be to human health, and that women and men may experience different diseases as a result,” said first author Dr. Jenny Censin. For the study, the team from Oxford University analyzed genetic information and three different obesity measures in a cohort of 195,041 men and 228,466 women.
A new study has found that if people with type-2 diabetes achieve just 10% weight loss within 5 years of being diagnosed, they are twice as likely to experience remission at the 5-year follow-up as those who haven’t lost any weight. The findings of the study by researchers from Cambridge appear in the journal Diabetic Medicine and were obtained through analysis of 867 people aged 40-69 with newly diagnosed type-2 diabetes. Having followed the study participants for 5 years, the researchers found that 257 (30%) had diabetes in remission. Speaking about their findings, first author Hajira Dambha-Miller, Ph.D. said: “Our results suggest that it may be possible to get rid of diabetes, for at least 5 years, with a more modest weight loss of 10%. This will be more motivating and hence more achievable for many people.” The fact diabetes can be sent into remission with just moderate weight loss – and not just the drastic intensive weight loss measures we’ve known about for some time - will be welcome news for many people living with the condition. It reinforces the importance of managing one’s weight through dietary choices and physical exercise. Going forward, the Cambridge team hopes to be able to use the research to help medical professionals better support patients with type-2 diabetes and reduce their symptoms.
The method via which a baby is born has a dramatic impact on its gut bacteria and could explain why babies born by Caesarean section are more likely to experience health problems later in life, a new study has found. The study by Wellcome Sanger Institute, UCL, and the University of Birmingham – the largest of its kind – looked at babies’ microbiomes (the bacteria, viruses and fungi that live in our guts) to see if they formed differently depending on how a baby was born. For the research, samples were taken on a regular basis from the nappies of 600 babies in their first month of life. The results showed that vaginally born babies got most of their first bacteria from their mothers. However, babies born via Caesarean section showed high levels of hospital bugs, with some having as much as 30% of their total microbiomes made up by such bugs. It’s a reality that could explain why babies born by Caesarean section are more susceptible to certain conditions when they are older, like allergies, asthma and type 1 diabetes. Speaking about the findings of the research, Dr Trevor Lawley, from the Wellcome Sanger Institute, said: “What surprised me and scared me was the amount of healthcare bugs showing up in these children. “But what excites me is we have an amazing body of data now that we can build on, to think about how to properly establish the human ecosystem, starting at birth.”
Simple educational and motivational text messages can help people with diabetes manage their blood sugar better, a new study has found. It is not only an extremely affordable and scalable measure, but one that can be applied globally. According to the six-month Chinese study, diabetes patients who received the text messages and standard care reduced their glycated hemoglobin (HbA1c ) by more than patients who just received standard care. The results showed an average reduction in HbA1c of 2 mmol/mol (0.2%) in patients who received the supportive text messages. The group that did not receive the text messages experienced an average increase in HbA1c of 1 moll/mol (0.1%). For the study, the participants were split into two groups: one that received standard diabetes care and two text messages each month thanking them for their participation, and another group that received standard care and up to six text messages per week containing information on subjects like dietary advice, physical activity, emotional support and blood glucose monitoring. As well as actually reducing their HbA1c, the group receiving the supportive text messages also had a greater proportion of patients who achieved their HbA1C target of less than 7% (69.3% vs. 52.6% in the control group). Speaking about the findings of the study, Dr Xiqian Huo, of Beijing's Fuwai Hospital, said: “Lifestyle advice such as strict dietary control may have contributed to glycemic improvements, together with reminders to monitor blood glucose regularly. The messages were designed to provide information and motivation, and help patients set goals and manage stress.” The results of the study were presented at the annual meeting of the European Society of Cardiology on Saturday, August 31 also appear in journal Circulation: Cardiovascular Quality and Outcomes.
People with type-2 diabetes get no benefit from taking omega-3 fish oil supplements, a new study has found. According to researchers from the University of East Anglia, while omega-3 supplements are not harmful for people with type-2 diabetes (this has been a concern previously), they don’t provide any benefit either. This contradicts a common belief that omega-3 can protect against diabetes and even reverse the condition. The study, which involved 58,000 participants, found that people who consumed more omega-3 had the same risk of developing diabetes as individuals who did not. Furthermore, taking omega-3 fish oil did not influence levels of blood glucose, insulin and glycated haemoglobin - all measures of how the body handles sugar. ‘Better to eat fish’ Douglas Twenefour, deputy head of care at Diabetes UK, said: “Eating a healthy, varied diet is incredibly important, and we know that certain foods - including fruits, vegetables, wholegrains, yoghurt and cheese - can help to lower your risk of type 2 diabetes. “While omega-3 fatty acids are crucial for our overall health, it's generally better for people with type 2 diabetes to get their intake by eating at least two portions of oily fish a week, than by taking supplements." The advice from Dr Lee Hooper, who led the research, is to forego the expensive omega-3 supplements and instead buy oily fish and/or spend your money on physical activity, which will have more of a positive impact when it comes to type-2 diabetes.
Postmenopausal women who have more fat on their legs and thighs have less risk of stroke or heart disease than their peers who carry fat around their stomach, a new study has found. As a result of the research, the findings of which appear in the European Heart Journal, scientists say women should aim to be more “pear-shaped” than “apple-shaped”. For the research, scientists followed 2,600 women with BMIs of between 187 and 25 for 18 years. The scientists found that the women who were apple-shaped i.e. had fat around their stomachs were more than three times more likely to develop cardiovascular disease than the women who were pear-shaped i.e. had fat on their legs and thighs. It’s already known that fat stored in the visceral region (around the abdominal organs) can increase a person’s chances of developing type-2 diabetes and cardiovascular problems, but the exact reasons why remain unknown. Further research is needed. The advice for women (and men) is to reduce the amount of fat they have stored around their stomachs. Speaking about the findings of the study, Dr Sonya Babu-Narayan, associate medical director at the British Heart Foundation, said: “This study uncovers an interesting link between where fat is stored and your risk of heart attack and stroke, but can't tell us why it exists. “Future research to uncover how the distribution of body fat is related to these diseases could reveal important new ways to prevent and treat the world's biggest killer.”
A major study has found that the UK has a big obesity problem, and that there are severe health implications for people who are even just a little overweight. According to the research, which was funded by healthcare firm Novo Nordisk, individuals with a Body Mass Index (BMI) of 30-35 were 70% more likely to develop heart failure than their healthy weight peers (18.5-25 BMI). Furthermore, the study of 2.8 million adults also showed that people who were even slightly overweight were twice as likely to develop Type 2 diabetes. The study, which is due to be presented at the European Congress on Obesity (ECO) in Glasgow, also revealed: The risk of Type 2 diabetes for people with a BMI of 35-40 was almost nine times higher People with severe obesity (BMI of 40-45) were 12 times more likely to develop Type 2 diabetes People with severe obesity also had triple the risk of heart failure, high blood pressure, and dyslipidaemia (elevated levels of total or low-density lipoprotein (LDL) cholesterol levels, or low levels of high-density lipoprotein (HDL) cholesterol) A BMI of 40-45 was also linked with a 50% higher risk of dying prematurely from any cause Speaking about the findings of the study, Public Health England said “sustained action” was needed to tackle obesity.
Following a low-calorie diet – even for just a few months – can arrest type-2 diabetes for at least two years, new research suggests. The findings of the study highlight that type-2 diabetes might not necessarily be the life sentence we previously thought. Nearly 300 people with type-2 diabetes in Scotland and Tyneside (in the UK) participated in the study. Half were given standard diabetes care, while the other half were put on a structured weight management programme. After 12 months, 46% of those on the low-calorie programme had successfully reversed their type-2 diabetes. In comparison, just 4% of the study participants given the standard treatment had gone into remission. Two years later, 36% of the study participants on the structured weight management programme were still in remission. “People with type 2 diabetes and healthcare professionals have told us their top research priority is: ‘Can the condition be reversed or cured?’ We can now say, with respect to reversal, that yes it can. Now we must focus on helping people maintain their weight loss and stay in remission for life,” said Prof Mike Lean from Glasgow University, who led the study with Taylor. Type-2 diabetes causes blood sugar levels to rise and can lead to serious complications such as amputations, visual problems and heart disease. It is thought that one in 16 adults in the UK is currently living with type-2 diabetes, a condition that is fuelled by obesity. [Related reading: Why being overweight increases your risk of cancer]
A new study has revealed that half of UK adults cannot name a single dementia risk factor. If asked, how many could you name? The study by Alzheimer's Research UK found that just 1% of UK adults could name the seven known dementia risk or protective factors. Heavy drinking, smoking, genetics, high blood pressure, depression and diabetes are the six dementia risk factors, while physical exercise is a protective factor. According to the study, more than half of UK adults know someone with dementia, yet only half also recognised that the disease is a cause of death. Furthermore, a fifth of people quizzed for the report incorrectly said that dementia is an inevitable part of getting old. Right now, there are more than 850,000 people in the UK living with dementia and that number is expected to top one million by 2025. Alzheimer's disease is the most common type of dementia, accounting for around two-thirds of all cases. Hilary Evans, chief executive of Alzheimer’s Research UK, said: “It is a sad truth that more people are affected by dementia than ever before and half of us now know someone with the condition. Yet despite growing dementia awareness, we must work harder to improve understanding of the diseases that cause it.” You can read the full Alzheimer’s Research UK report here: https://www.dementiastatistics.org/wp-content/uploads/2019/02/Dementia-Attitudes-Monitor-Wave-1-Report.pdf#zoom=100
People who have sedentary jobs could significantly boost their lifespans by taking short, regular movement breaks, a new study has found. It’s no secret that individuals who spend a lot of time sitting down are more likely to develop certain adverse health conditions, such as diabetes, obesity and cardiovascular diseases, as well as having increased risk of osteoporosis, depression, anxiety, colon cancer and high blood pressure. However, just a small amount of exercise, the study suggests, could lower the risk of early death. According to the research – the findings of which are published in the Annals of Internal Medicine – individuals who sat for less than 30 minutes at a time had the lowest risk of early death. For example, workers who had a movement break (involving some low-intensity exercise) every 30 minutes had a 17% lower risk of death than their counterparts who did not have any breaks. Moreover, individuals who broke up periods of sitting every 30 minutes with moderate- to high-intensity exercise lowered their risk of early death by 35%. Speaking about the findings of the research, Keith Diaz, an assistant professor of behavioural medicine at Columbia University Vagelos College of Physicians and Surgeons in New York City and study lead, said: “If you have a job or lifestyle that involves a lot of sitting, you can lower your risk of early death by moving more often, for as long as you want and as your ability allows — whether that means taking an hour-long high-intensity spin class or choosing lower-intensity activities, like walking.”
The health benefits of eating fiber have long been hailed, but how much fiber should we all be eating to prevent chronic disease and premature death? A new study reveals just that… Commissioned by the World Health Organization (WHO), the research is the culmination of a meta-analysis of observational studies and clinical trials that took place over almost 40 years. The results appear in the journal The Lancet. One of the objectives of the research was to help in the development of new guidelines for dietary fiber consumption, as well as discover which carbs protect us the most against noncommunicable diseases. So how much fiber should we be eating? Well, the research found that a daily intake of 25–29 grams of fiber is ideal. People who consumed this amount of fiber each day were 15–30 percent less likely to die prematurely from any cause and had a 16–24 percent lower incidence of stroke, coronary heart disease, type 2 diabetes, and colon cancer. The researchers also say that consuming more than 29 grams of fiber per day could lead to even more health benefits. Speaking about the findings of the study, Professor Jim Mann, of the University of Otago, in New Zealand, said: “The health benefits of fiber are supported by over 100 years of research into its chemistry, physical properties, physiology, and effects on metabolism. “Fiber-rich whole foods that require chewing and retain much of their structure in the gut increase satiety and help weight control and can favorably influence lipid and glucose levels. “The breakdown of fiber in the large bowel by the resident bacteria has additional wide-ranging effects including protection from colorectal cancer.” Fiber-rich foods include vegetables, whole grains, fruit, and pulses, such as beans, peas, lentils, and chickpeas. Are you consuming enough fiber?
According to the World Health Organization (WHO), obesity is a “global epidemic” that must be tackled if we are to prevent its ill effects. In the United States, nearly 40% of adults and 18.5% of children aged 2 to 19 are obese. Obesity is a major risk factor for type-2 diabetes, heart disease and some types of cancer. That’s why finding effective ways to treat the condition is paramount. But now scientists say they are on the verge of creating a pill that could make obesity a thing of the past - without the need for diet and exercise. Sounds too good to be true, right? Nevertheless, the team at Flinders University in South Australia say that they key to curbing obesity could lie in a single gene known as RCAN1. The team found that when RCAN1 was removed in mice and they were then fed a high fat diet, they did not gain weight. In fact, they could eat as much food as they wanted over a prolonged period of time, the researchers say. Damien Keating, Ph.D., professor of molecular and cellular physiology at Flinders, and leader of the research team, said blocking RCAN1 allows the body to transform unhealthy white fat into calorie-burning brown fat. Stunning pictures of the mice used for the trial highlight the difference when RCAN1 was blocked and when it wasn’t. The results of the research are published in the journal EMBO Reports.
A new study, one of the largest of its kind, suggests being the wrong weight i.e. overweight or underweight cold knock four years off a person’s life expectancy. According to the study, the findings of which were published in the Lancet Diabetes and Endocrinology journal, from the age of 40, people towards the higher end of the healthy Body Mass Index (BMI) range (a healthy BMI ranges from 18.5 to 25) had the lowest risk of dying from disease, including cancer and heart disease. In contrast, individuals who had BMI scores of less than 18.5 or more than 30 had life expectancies that were 4.4 years and 3.85 years shorter respectively. BMI scores, which are calculated by dividing a person’s weight (in kilograms) by their height (in metres squared), are still considered by health professionals to be the simplest and most accurate way to work out if someone is overweight or underweight. For the population-based cohort study, researchers analysed anonymised data on 3.6 million adults from the U.K. Clinical Practice Research Datalink (CPRD). Dr Krishnan Bhaskaran, lead author of the study, said: “The most striking thing about our findings was how widely BMI was linked to different causes of death. BMI was associated with deaths from nearly all major causes.” He added that the research reinforces the importance of maintaining a healthy body weight. Perhaps the most interesting finding is that people who have low BMI scores are at as much risk, if not more, of reducing their life expectancies.
The physical health problems associated with diabetes are well understood and publicised. For example, diabetics have an increased risk of developing cancer, kidney disorders and cardiovascular disease. But what about the mental impact of living with diabetes? It’s not something that gets a lot of attention, but the findings of a new study could see it thrust under the spotlight. That’s because the study by researchers from Finland found a worrying connection between diabetes and the risk of someone dying by suicide or alcoholism. According to the study, diabetics are more than 10 times more likely to die as a result of alcoholism – predominantly cirrhosis of the liver – and 110% more likely to commit suicide than the general population. The highest risk was seen among diabetes patients who rely on regular insulin injections to avoid serious health complications. Professor Leo Niskanen, of the University of Helsinki, who led the study, said diabetes patients who have to monitor their glucose levels and administer insulin frequently suffer tremendous mental strain. “This strain combined with the anxiety of developing serious complications like heart or kidney disease may also take their toll on psychological well-being,” he said. Is it time we started talking about the mental health implications of living with diabetes? [Related reading: Type-2 diabetes could actually be detected up to 20 years in advance, researchers say]
Some of the warning signs often associated with type-2 diabetes can be detected years before the disease is actually diagnosed, researchers say. A study found factors such as insulin resistance and elevated blood sugar levels were seen in people years prior to them developing pre-diabetes – a typical pre-cursor to the type-2 form of the disease. The authors of the Japanese study say their findings suggest that diabetes treatment should begin much earlier in life. For the study, conducted over an 11-year period, the researchers followed a group of 27,000 people who were not diabetic and aged between 30 and 50. The individuals were tracked until they either (a) got diagnosed with type-2 diabetes; (b) got diagnosed with pre-diabetes; or (c) the end of 2016 was reached. During the study, 1,067 new cases of type-2 diabetes were diagnosed. The interesting part is that these people showed warning signs, such as insulin resistance and higher fasting blood sugar levels, up to 10 years prior. Similar warning signs were also seen in those that went on to develop pre-diabetes. So, this suggests that type-2 diabetes could actually be detected up to 20 years before a diagnosis occurs. This is because people who develop type-2 diabetes usually get pre-diabetes first. Dr Hiroyuki Sagesaka, from Aizawa Hospital in Matsumoto, Japan, who led the research, said: “Because trials of prevention in people with pre-diabetes seem to be less successful over long-term follow-up, we may need to intervene much earlier than the pre-diabetes stage to prevent progression to full blown diabetes. “A much earlier intervention trail, either drug or lifestyle-related, is warranted.” [Related reading: Diabetes is actually five diseases, not two]
Have you ever received a letter from your doctor or physician and not been able to clearly understand its contents? If you have, we’ve got some positive news for you. That’s because the Academy of Medical Royal Colleges is urging doctors to do away with medical jargon in correspondence to patients and use easy to understand terms instead. For example, the academy says the term “twice daily” is much better than the often used Latin abbreviation “bd”, and says patients should ask their local hospital to follow the advice. Oftentimes, hospital doctors write letters directly to a patient’s GP and refer to the patient in the third person. However, this can lead to things being misinterpreted and even the patient being offended. The academy cites the example of a father who was praised for “manfully stepping in” when his wife could not take their daughter to an appointment because she (the wife) was too ill. Doctors are also being asked to try and soften potentially sensitive information and avoid stigmatising words. For example, “You have diabetes,” is better than “You are diabetic.” The initiative is being led by Dr Hugh Rayner, a kidney specialist, who has been writing to patients directly since 2005. He said: “The change may seem small but it has a big effect. “Writing to patients rather than about them changes the relationship between doctor and patient. “It involves them more in their care and leads to all sorts of benefits.”
Dans le monde, l’espérance de vie s’allonge, mais la mauvaise alimentation est responsable de près d’un décès sur 5. Bonne nouvelle : dans le monde, l’espérance de vie s’allonge et la mortalité infantile baisse, selon une étude coordonnée par l’Institut de mesure et d’évaluation de la santé à l’Université de Washington à Seattle (IHME), publiée vendredi, qui compile des données de 195 pays et territoires. L’étude a également exploré les causes de décès dans le monde. Allongement de la durée de vie En un demi-siècle, l’espérance de vie moyenne tous sexes confondus a augmenté de 14 ans: elle est aujourd’hui de 72,5 ans (75,3 ans chez les femmes, et 69,8 ans chez les hommes), contre 58,4 ans en 1970. C’est le Japon qui détient le record de l’espérance de vie moyenne la plus élevée, 83,9 ans pour les deux sexes combinés. La Centrafrique a la plus basse, 50,2 ans en moyenne. «Les gens vivent plus longtemps», se réjouit le Dr Christopher Murray, directeur de l’IHME. Il ajoute avoir constaté avec ses collègues au cours de la dernière décennie des «progrès importants», comme la baisse de la mortalité infantile et du paludisme. En effet, les décès d’enfants de moins de 5 ans sont passés pour la première fois en dessous de 5 millions en 2016, trois fois moins qu’il y a 50 ans (16,4 millions en 1970). Un décès sur cinq dans le monde serait lié à une mauvaise alimentation De nombreuses données de l’étude pointent toutefois les problèmes liés au mode de vie, en particulier à une mauvaise alimentation. Sur les 54,7 millions de décès constatés en 2016 dans le monde, 72% sont causés par des maladies non transmissibles (affections cardiovasculaires, diabète) souvent liées au mode de vie: alimentation, sédentarité, tabac, alcool, etc. Près d’un décès sur cinq serait provoqué par une mauvaise alimentation, en particulier celle pauvre en céréales complètes, fruits et légumes, noix et poissons. Les auteurs soulignent que parmi toutes les formes de malnutrition, les mauvaises habitudes alimentaires représentent le principal risque de mortalité. L’alimentation trop salée est par exemple associée à un peu plus de dix millions de décès (18,8%) dans le monde. Il n’est donc pas étonnant que parmi les dix principaux facteurs de risque de décès on retrouve l’obésité, un excès de cholestérol sanguin, et une glycémie (taux de sucre dans le sang) et une pression artérielle élevées. Le tabac est lui responsable d’un peu plus de 7 millions de décès.
It’s thought around one in 100 babies has genes that place them at increased risk of developing type 1, insulin-dependent diabetes. And unfortunately, at present, there is no way to prevent type 1 diabetes. But experts believe a new technique may be able to prevent high-risk babies from developing the condition. The idea is to use powdered insulin to train the immune systems of infants so that they are afforded life-long protection. Pregnant women attending maternity check-ups in Berkshire, Buckinghamshire, Milton Keynes and Oxfordshire in the UK are being asked to take part in the trial. Trial participants will be split into two groups, with half getting real insulin and the other half a placebo. Neither the participants nor the researchers will know which they received until after the trial. By spoon-feeding an infant insulin powder from six months to three years, experts hope their immune systems will be trained to tolerate insulin and prevent type 1 diabetes. A lifelong condition, type 1 diabetes is an autoimmune disease which causes insulin-producing cells in the pancreas to be destroyed. As a result, the pancreas doesn’t produce any insulin and the person's blood sugar (glucose) level becomes too high. Speaking about the trial, Dr Elizabeth Robertson, director of research at Diabetes UK, said: "This is a huge endeavour, so we would encourage women living in the South East who think they might be eligible to find out more - research like this can't happen without the incredible people who take part." [Related reading: Diabetes is actually five diseases, not two]
Une étude coréenne montre que la pollution atmosphérique est néfaste pour la flore cutanée. Depuis quelques années, les études sur la flore intestinale (ou microbiote intestinal) se multiplient. Côlon irritable, maladie de Crohn, diabète, obésité... Un bouleversement de ces «bons» microbes est bien souvent corrélé à des problèmes de santé. Moins connus en revanche est le microbiote cutané, composé de millions de bactéries, virus et champignons recouvrant notre peau. Pourtant, eux aussi préservent notre organisme des infections, de l’acné, de l’eczéma, voire du mélanome (cancer de la peau). La ville, un environnement mauvais pour la peau Notre peau et son microbiote sont en première ligne face aux agressions de l’environnement, comme la pollution atmosphérique. Une récente étude coréenne a même montré que plus la ville dans laquelle on vit est grande et urbanisée, moins le microbiote cutané est de qualité. Ces travaux, publiés le 7 mars dans le journal Sciences Advances ont consisté à analyser la diversité du microbiote prélevé sur la joue de plus de 200 Chinoises en fonction de leur lieu de résidence. «Si le microbiote cutané asiatique n’est pas comparable au microbiote caucasien (européen), souligne le Pr Patrice Debré, immunologiste à l’hôpital de la Pitié Salpêtrière (AP-HP) et auteur du livre L’Homme microbiotique , l’étude coréenne a l’avantage de pointer du doigt l’effet de l’environnement souvent ignoré». Le médecin appel toutefois à la prudence: «la pollution en Chine n’est pas la même qu’en France. S’il est loin d’être absurde de penser que l’air des villes françaises peut aussi affaiblir notre microbiote, il reste à le démontrer». Un microbiote cutané au service de nos défenses immunitaires Une chose est sûre en revanche, si la diversité du microbiote est altérée (réduite ou trop élevée), l’équilibre est rompu et la peau devient plus fragile face aux infections et aux allergies. «C’est un peu comme pour les chaises musicales, commente le Pr Debré, si de «bonnes» bactéries occupent la place sur notre peau, les «mauvaises» ne peuvent pas s’y installer». En outre, les bactéries du microbiote (bactéries commensales) sont capables de tuer les autres bactéries pathogènes soit par la production de bactéricides, soit par la stimulation de notre propre système immunitaire. Ainsi, un dérèglement du microbiote - appelé dysbiose — peut donc engendrer de multiples problèmes de peau. On sait par exemple, que l’acné est due à une prolifération de certaines variétés de bactéries P. acnes qui engendrent l’apparition de boutons. Pour la dermatite atopique, caractérisée par des poussées d’eczéma, c’est la prolifération de staphylocoques dorés qui est en cause. Or cette bactérie ne prolifère que si le microbiote est appauvri, entraînant de multiples réactions inflammatoires à l’origine des éruptions cutanées. «On pense même aujourd’hui, qu’un microbiote en bonne santé pourrait réduire le risque de développer un mélanome», explique le Pr Brigitte Dréno, dermatologue au CHU de Nantes.
Doctors should take a person’s marital status into account when assessing their risk of heart attack and stroke, a major study has found. For the study, researchers at Keele University analysed numerous trials involving more than two million people. They found that individuals who were never married, divorced or widowed were 42% more likely to develop cardiovascular disease. They were also 42% more likely to die from heart disease and 55% more likely to die from a stroke. Risk factors such as age, sex, high cholesterol, high blood pressure, smoking, and diabetes are usually associated with cardiovascular disease. However, the findings of the new study suggest marital status should also be added to the list. Senior author, Mamas Mamas, Professor of Cardiology at Keele University, in England, said: “Our work suggests that marital status should be considered in patients with or at risk of developing cardiovascular disease, and should be used alongside more traditional cardiac risk factors to identify those patients that may be at higher risk for future cardiovascular events”. The researchers say the reason marriage could have a protective effect on cardiovascular disease is because of the additional emotional and social support that’s afforded by having a spouse. People with long-term partners are more likely to have symptoms spotted earlier and encouraged to seek medical advice as a result.
Have you ever encountered someone who calls themself ‘fat but fit’? It’s not uncommon to meet people who are clearly overweight, yet not perturbed by their situation because they consider themselves to be fit and healthy. However, a large study conducted in America has found that women who are overweight or obese but otherwise healthy are still at an increased risk of cardiovascular disease (CVD). For the study, researchers from the German Institute of Human Nutrition Potsdam-Rehbruecke tracked the health of some 90,257 women in the US over a 30-year period. They found that women who were overweight or obese, but had none of the typical cardiovascular risk factors, such as high blood pressure, excess cholesterol and diabetes, were 20% and 39% more likely to develop cardiovascular disease than their normal weight and metabolically healthy peers. Speaking about the findings of the study, Prof Matthias Schulze, who led it, said: "Our large cohort study confirms that metabolically healthy obesity is not a harmless condition, and even women who remain free of metabolic diseases for decades face an increased risk of cardiovascular events.” The study also found women who were of normal weight, but metabolically unhealthy, were over two-times more likely to develop cardiovascular disease than their peers of the same weight who were metabolically healthy. Jeremy Pearson, associate medical director at the British Heart Foundation, added: "This large scale study confirms that obesity, even if unaccompanied by other warning signs, increases risk of cardiovascular disease in women."
Most people are familiar with the phrase, ‘an apple a day keeps the doctor away’, but what about an egg a day? New research suggests that a daily egg may reduce the risk of heart disease and stroke. Despite sometimes getting a bad press for their high cholesterol content, eggs, it seems, could help us steer clear of cardiovascular conditions, according to research published in the journal Heart. For their study, researchers from the School of Public Health at Peking University Health Science Centre in Beijing, China analysed survey data relating to more than 500,000 individuals. Of those individuals, 461,213 were free from cancer, cardiovascular disease (CVD) and diabetes at baseline. Egg consumption among the study participants was noted and the individuals were followed up with after a median period of 8.9 years. The researchers' found that individuals who usually ate about one egg per day had a 26% lower risk of experiencing hemorrhagic stroke; a 28% lower risk of death due to this type of event; and an 18% lower risk of CVD-related mortality. Current NHS guidelines in the UK relating to egg consumption state: "although eggs contain some cholesterol, the amount of saturated fat we eat has more of an effect on the amount of cholesterol in our blood than the cholesterol we get from eating eggs". So, in other words, it’s not eggs that are necessarily the problem when it comes to cholesterol, but rather how you cook them. Indeed, eggs are a great source of healthful nutrients, such as protein, vitamins, phospholipids, and carotenoids.
While a low sperm count and problems with sperm quality are huge hurdles for couples who are trying to get pregnant, a new study shows that men with low sperm counts are also at increased risk of illness. The study of 5,177 men in Italy found that those with low sperm counts were 20% more likely to have more body fat, more "bad" cholesterol and higher blood pressure – all factors that increase the risk of developing diabetes, heart disease and stroke. They were also 12 times more likely to have low testosterone levels. Dr Alberto Ferlin, from the University of Bresci, who led the study, said: "Infertile men are likely to have important co-existing health problems or risk factors that can impair quality of life and shorten their lives. "Fertility evaluation gives men the unique opportunity for health assessment and disease prevention." The study’s authors say that men with low sperm counts should be actively checked for other potential health problems, which may have a greater chance of being rectified if treated earlier. However, the authors of the study stressed that their findings did not prove that low sperm counts cause metabolic problems, merely that the two are linked in some way.
Diabetes has long been split into two types: type 1 and type 2. But new research suggests it could actually be five different diseases and treatment could be tailored to tackle each form. Researchers in Sweden and Finland say the more complicated diabetes picture they’ve uncovered could lead to a new era of personalised medicine being ushered in. Affecting approximately one in 11 people around the world, diabetes doesn’t just play havoc with blood sugar levels, but also increases the risk of stroke, blindness, heart attack, kidney failure and limb amputation. Type 1 diabetes, which affects around 10% of sufferers in the UK, is a disease of the immune system that attacks the body’s insulin factories, leading to there being a shortage of the hormone to control blood sugar levels. Type 2 diabetes, on the other hand, is associated with poor lifestyle choices and obesity, which affect the way in which insulin works. For the study, the researchers analysed blood samples from 14,775 patients. They found that people could be separated into five distinct diabetes clusters. Talking to the BBC, Prof Leif Groop, one of the researchers, said: "This is extremely important, we're taking a real step towards precision medicine. "In the ideal scenario, this is applied at diagnosis and we target treatment better."
A study conducted in Yorkshire, Derbyshire and Nottinghamshire in the UK has found that offering new mothers financial incentives in the form of shopping vouchers boosts breastfeeding rates. For the study, more than 10,000 mothers were offered up to £200 in shopping vouchers as an incentive to breastfeed. The vouchers could be used to buy food, household items, toys, clothes, books or DVDs in supermarkets and other shops. Breastfeeding levels are among the lowest in the world, with just 12% of new mothers in some areas feeding their six to eight week-old babies this way. However, with the voucher incentive scheme, breastfeeding rates in the areas involved rose by 6%. The women were given vouchers worth £120 if they signed declaration forms stating their babies had been breastfeed for the first six weeks of their lives. The mothers received a further £80 of vouchers if they were still breastfeeding after six months. Principal investigator Dr Clare Relton, from the University of Sheffield’s School of Health and Related Research (ScHARR), said: “Our scheme offered vouchers to mothers as a way of acknowledging the value of breastfeeding to babies and mothers and the work involved in breastfeeding. “The trial found a significant increase in breastfeeding rates in areas where the scheme was offered. “It seems that the voucher scheme helped mothers to breastfeed for longer. Mothers reported they felt rewarded for breastfeeding.” NHS guidelines say that babies should be exclusively breastfeed for at least the first six months of their lives. Babies that are breastfed have fewer health problems in their younger years and are less likely to develop conditions such as diabetes when they are older. The five-year trial was funded by research councils, medical charities and Public Health England.
A “watershed” trial involving almost 300 people has seen nearly half the participants reverse their type 2 diabetes in just five months. Trial participants followed a low-calorie diet of soups and shakes for up to five months, which led to massive weight loss. One participant, Isobel Murray, 65, who had weighed 15 stone, lost over four stone (25kg) and now no longer needs diabetes pills. "I've got my life back," she says. Prior to the trial, Isobel’s blood sugar levels were too high and her diabetes medication was being increased on a regular basis. So, she went on to the all-liquid diet for 17 weeks and gave up both cooking and shopping. She didn’t even eat meals with her husband during the trial. Following the trial, 46% of participants were in remission a year later and 86% who lost 15kg (2st 5lb) or more put their type 2 diabetes into remission. Just 4% went into remission with the other best treatments currently used. Speaking about the results of the trial, Prof Mike Lean, from Glasgow University, said: "It's hugely exciting. We now have clear evidence that weight loss of 10-15kg is enough to turn this disease (diabetes) around.” The charity Diabetes UK says the trial is a landmark and has the potential to help millions of patients. The findings of the trial, which was conducted by the universities of Newcastle and Glasgow in the UK, were published in The Lancet and presented at the International Diabetes Federation.
A leading UK-based cancer charity has warned that many people could be missing the symptoms associated with pancreatic cancer and not receiving treatment that could extend their lives as a result. Pancreatic Cancer UK says that as many as one in three adults could ignore the warning signs and symptoms of potential pancreatic cancer, simply because they don’t know what to look for. Indigestion, stomach ache, unexplained weight loss and faeces that float rather than sink in the toilet are all signs of the potentially deadly disease. At present, just one person in 10 survives longer than five years after being diagnosed with pancreatic cancer. Early detection and treatment are vital for saving lives. The charity’s survey of 4,000 people suggests many people take the symptoms for granted, with 35% of respondents saying they would not be anxious if they were suffering from a few of the signs of the disease. Speaking about the results of the survey, Pancreatic Cancer UK chief executive Alex Ford said: ““We must all be aware of the possible signs of pancreatic cancer, and of the devastating impact this disease can have, because 93% of people diagnosed will not live beyond five years”. Common symptoms of pancreatic cancer include: stomach and back ache unexplained weight loss indigestion changes to bowel habits, including floating faeces Other symptoms include: loss of appetite jaundice (yellow skin or eyes) itchy skin feeling and being sick difficulty swallowing recently diagnosed diabetes
We recently reported that childhood obesity rates are 10 times higher today than they were in 1975. This worrying trend is only set to continue unless more is done to tackle obesity in children. So-called “sugar taxes” on soft drinks in various countries around the world and France’s decision to ban unlimited fizzy drinks in restaurants, fast food-chains, schools and holiday camps, are definitely steps in the right direction. Now, hospitals in England have laid out plans to ban the sale of any sweets or chocolate that contain more than 250 calories. Going forward, super-sized chocolate bars will become a thing of the past in hospital vending machines and canteens. In addition, pre-packed sandwiches with more than 450 calories and/or 5g of saturated fat per 100g will also be banned. Hospitals will be given a cash boost to help them facilitate the changes. The decision to ban fattening and sugary food products in hospitals is actually win-win for the National Health Service (NHS). These foods are major contributors to obesity and many other conditions/diseases, such as preventable diabetes, tooth decay, heart disease and cancer – all of which put enormous strain on the health service. Public Health England says hospitals have an "important role" in tackling obesity and not just dealing with the consequences.
Whether you call them love handles or muffin tops, the areas of built up fat that can appear above your waistline are something that many people would love to be able to easily get rid of. A new patch developed by scientists in the US could provide the easy fix people have been looking for. The novel patch delivers fat-browning drugs directly into the areas of fat and converts "bad" white fat into "good" brown fat - not only reducing the amount of excess fat, but also lowering fasting blood glucose levels. Having too much white fat - particularly around the abdominal region - can raise the risk of several health problems, including diabetes and heart disease. So far, the patches have only been trialled on mice, but it’s hoped that they can be developed for human use in the future. Study co-leader Li Qiang, Ph.D., from the Columbia University Medical Center in New York City, said the patches could offer a great alternative to existing drugs that promote fat browning. Their non-invasive nature can reduce side effects. "The nanoparticles were designed to effectively hold the drug and then gradually collapse, releasing it into nearby tissue in a sustained way instead of spreading the drug throughout the body quickly," says study co-leader Zhen Gu, Ph.D., from the University of North Carolina at Chapel Hill and North Carolina State University in Raleigh.
A study of nearly a million UK adults has found that being married appears to be good for your health, boosting your chances of survival if you have a major heart risk factor, like high cholesterol. All of the individuals involved in the study had high blood pressure, cholesterol or diabetes and the researchers discovered the ones who were married fared much better than those who were single. Dr Paul Carter and colleagues from Aston Medical School presented the findings of their study at the British Cardiovascular Society conference. They believe that having something special in your life is what’s important, rather than simply being married. At the end of their 14-year ACALM study, the researchers found that married men and women in their 50s, 60s and 70s with high cholesterol had a 16% greater chance of being alive than their single counterparts. Dr Carter said: "We need to unpick the underlying reasons a bit more, but it appears there's something about being married that is protective, not only in patients with heart disease but also those with heart disease risk factors. "We're not saying that everyone should get married though. "We need to replicate the positive effects of marriage and use friends, family and social support networks in the same way." Dr Mike Knapton, of the British Heart Foundation, said: "The take-home message is that our social interactions, as well as medical risk factors such as high blood pressure, are important determinants of both our health and wellbeing. "Whether you are married or not, if you have any of the main risk factors for heart disease, then you can call upon loved ones to help you to manage them."
Men with waists over 40 inches and women with waists over 35 inches are at greater risk of certain cancers, as well as type 2 diabetes. That’s the message to come out of a study by scientists at the International Agency for Research on Cancer (IARC), which is an arm of the World Health Organisation. According to Dr Heinz Freisling, the lead author of the study published in the British Journal of Cancer, a person’s waist measurement is as good at predicting cancer risk as their body mass index (BMI). His advice is for people to know their waistlines. “You only need to put a tape measure around your belly button. This is easy to do and can give a person an indication of whether their risk for specific cancers is increased or not – for instance pancreas or liver cancer which are known to be related to increased body fatness or obesity,” he said. Being overweight or obese is the single biggest preventable cause of cancer after smoking and is linked to 13 types of cancer, including bowel, breast and pancreas. The study combined data from about 43,000 participants who had been followed for an average of 12 years and more than 1,600 people were diagnosed with an obesity-related cancer.
While the association between a lack of exercise and an increased risk of chronic diseases, including type 2 diabetes and heart disease, is well-established, new research shows that just 14 days of physical inactivity can increase a person's risk of such conditions. A study by the University of Liverpool found that young, healthy adults who switched from moderate-to-vigorous activity and then to near-sedentary behaviour for just 14 days experienced metabolic changes that could raise their risk of chronic disease and even premature death. Presenting their findings at the European Congress on Obesity 2017 in Portugal, Study leader Dr. Dan Cuthbertson and colleagues said that reducing physical activity for just 14 days led to a loss of skeletal muscle mass in the participants. However, the reduction of physical activity for 14 days also led to an increase in total body fat. Furthermore, said body fat was most likely to accumulate centrally, which the team notes is a significant risk factor for chronic disease. Current guidelines recommend that adults aged 18-64 undertake at least 150 minutes of moderate-intensity physical activity or 75 minutes of vigorous-intensity physical activity every week. However, the Centers for Disease Control and Prevention (CDC) says that fewer than 50% of adults meet these exercise recommendations. Are you doing enough exercise each week? Even just small lifestyle changes can make a big difference when it comes to your risk of chronic disease.
People with non-O blood could be at greater risk of stroke and heart attack, research suggests. Scientists say it's because A, B and AB blood contains higher levels of a blood-clotting protein. The research, which was presented at the 4th World Congress on Acute Heart Failure, analysed studies involving 1.3m people. It found that people 15 in 1,000 people with non-O blood suffered a heart attack, compared to 14 in 1,000 people with O blood. While these figures don't sound that startling at first, when applied to a whole population the numbers become more important. It is hoped that the findings will help doctors better identify who is at risk of developing heart disease. However, Dr Mike Knapton, associate medical director at the British Heart Foundation, said the findings would not have a large impact on the current advice issued by the charity. "Most of a person's risk estimation is determined by age, genetics (family history and ethnicity) and other modifiable risk factors including diet, weight, level of physical activity, smoking, blood pressure, cholesterol and diabetes. "People with a non-O blood group type - AO, BO and AB - need to take the same steps as anyone wanting to reduce their CVD risk." So regardless of your blood type, the advice remains the same: improve your diet, weight, level of physical activity and don't smoke. In addition, manage blood pressure, cholesterol and diabetes too. There's nothing you can do about your blood group, but you can make positive lifestyle changes to reduce your risk of heart attack and stroke.
Despite the fact the number of people who are overweight or obese has risen over the past 30 years, fewer people are actually attempting to shed weight, according to a new study, the findings of which were published in JAMA. Around two thirds of the adult population in the United States are obese or overweight, putting them at increased risk of heart disease, stroke, diabetes, and other chronic diseases. However, new research has found that even though there has been a significant rise in the number of people who are overweight or obese since the 1980s, the percentage of U.S. adults who are trying to lose weight has fallen. For their research, study co-author Dr. Jian Zhang and her colleagues from the Georgia Southern University, analysed the data of 27,350 U.S. adults aged between 20 and 59 years. The analyses revealed that the rates of overweight and obesity increased by 13%, from 53% in 1988-1994 to 66% in 2009-2014. Furthermore, the researchers also found that the percentage of people who attempted to lose weight over the same period actually dropped by 7%, from 56% in 1988-1994 to 49% in 2009-2014. At present, people are deemed to be overweight or obese depending on their body mass index (BMI). A BMI of 25 to under 30 is considered overweight, while a BMI of 30 or above is considered obese. A healthy diet and regular physical activity are proven to help curb weight gain, which is why we should all make a conscientious effort to watch what we eat and exercise more. [Recommended read: BMI Wrongly Labelling People Unhealthy, Finds New Research]
People should be cautious when purchasing medications online after an investigation uncovered "widespread failings" at some Internet-based providers, the Care Quality Commission (CQC) has said. The independent regulator of health and social care in England inspected 11 internet prescription services in the country and found some "potentially presenting a significant risk to patients". Despite some providers being well-run, others were cutting corners, according to the CQC investigation. For example, two online providers - Treated.com and MD Direct - did little or no checking of patients' identities. In addition, they were guilty of inadequate prescribing and gave no assurances that the clinicians working behind the scenes had the qualifications or relevant skills for the roles they were performing. Talking to BBC Radio 5 Live, Prof Steve Field, the CQC's chief inspector of general practice, said: ""Some of these websites prescribed unlicensed medicines and - even more worryingly - medicines for diabetes, Parkinson's disease, heart disease and Lithium for bipolar disorder." The CQC has now drawn up a set of clear standards for online pharmacies. Going forward, all Internet-based providers must: verify that a patient is who they say they are, such as through a Skype check obtain a comprehensive and up-to-date medical history ensure patients truly understand what medicines they are being given seek permission to contact a patient's GP One of the biggest problems cited with antibiotics being sold online is that some people treat them like sweets. More discipline is needed if we are to prevent the so-called antibiotic apocalypse - where bacteria become resistant to more and more drugs - from happening.
By simply cooking rice the wrong way, millions of people worldwide could be endangering their lives, scientists believe. That's because rice contains traces of the poison arsenic, which stems from industrial toxins and pesticides that can remain in the soil it grows in for decades. In fact, rice contains about 10-20 times more arsenic than other cereal crops because of the way it is grown in flooded paddies. Fortunately, the way people cook rice can have a dramatic effect on the amount of arsenic that finds its way into their bodies. Chronic arsenic exposure has been linked with cancer, diabetes, heart disease and developmental problems, which is why the new research is so alarming. For the BBC TV programme “Trust Me, I’m a Doctor,” Prof Andy Meharg, from Queens University Belfast, tested how three different ways of cooking rice affected the levels of arsenic in it afterwards. In the first method, he used a ratio of two parts water to one part rice. This is the method many people use and sees the water “steamed out” during cooking. It's also the method that resulted in the most arsenic remaining in the rice. In the second method, he used five parts water to one part rice and washed off the excess water. The levels of arsenic almost halved with this method. In the third and final method, he soaked the rice overnight before cooking it. This resulted in the levels of arsenic being reduced by a whopping 80%. "The only thing I can really equate it to is smoking," said Professor Meharg. "If you take one or two cigarettes per day, your risks are going to be a lot less than if you're smoking 30 or 40 cigarettes a day. It's dose-dependent - the more you eat, the higher your risk is."
The New Year is here and for many of you that will mean a new exercise regime designed to get you into shape and improve your overall health. For some people, though, sticking to a disciplined program of physical exercise is one of the hardest resolutions they can make because a lack of motivation gets in the way. But now new research sheds some light on why many people, despite understanding the benefits of regular exercise, find it hard in practice to stay physically active. Researchers from the Diabetes, Endocrinology, and Obesity Branch at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), led by Alexxai V. Kravitz, focused on why obese animals also have a hard time carrying out physical activity. They found that a dysfunction in obese rodents' dopamine systems might help explain why. Mice fed on a high-fat diet started gaining significantly more weight than mice fed on a normal diet. They were also observed to have fewer movements; spend less time moving; and were slower when they did move, compared with the lean mice. Most interesting of all was that the overweight mice's changes in movements did not correlate with body weight gain. Instead, the researchers found that a deficit in striatal D2R explained the obese mice's lack of activity. "In many cases, willpower is invoked as a way to modify behavior. But if we don't understand the underlying physical basis for that behavior, it is difficult to say that willpower alone can solve it," said Kravitz.
A leading bariatric surgeon in the UK has urged the government to offer gastric surgery to patients regardless of their weight. According to Professor Francesco Rubino, the Chair of Bariatric and Metabolic Surgery at Kings College, thousands of type-2 diabetes patients in the UK are missing out on vital weight loss surgery because they do not meet the NHS's guidelines when it comes to weight. That's because, at present, only type-2 diabetes patients who have a BMI of over 30 are currently eligible for bariatric surgery. Rubino says that weight loss surgery is "the closest thing to a cure" and should be used more often. In the UK, there are around 3.6 million people with type-2 diabetes, which costs the NHS up to £10 billion a year to treat. However, approximately 15% of sufferers are "normal weight" and so don't qualify for weight loss surgery under the NHS's current guidelines. "The biggest barrier we have is primarily one of stigma against obesity. The vast majority of the public believes this is a cosmetic intervention and unfortunately many physicians think the same way," said Rubino. Rubino also highlighted that weight loss surgeries, which manipulate the stomach or small intestine, do not just help people lose weight, but actually influence insulin production by altering hormones in the person's gut. "More than 50% of people with type 2 diabetes can enjoy long term remission. Another 30 or 40% enjoy a major improvement," he added.