Scientists believe they have discovered the reason why stress can make hair turn white. They’ve also found a potential way of preventing it from happening which doesn’t involve hair dye. In a chance finding while studying mice, the scientists noticed that dark-furred mice turned completely white within weeks after experiencing stress. The reason for this, the scientists say, is because the stress damaged stem cells that control hair and skin colour. The US and Brazilian researchers say their discovery is significant as it could lead to new treatments being developed that can protect hair colour from the effects of stress and ageing. Publishing their findings in the journal Nature, the researchers Universities of Sao Paulo and Harvard say the effects are linked to melanocyte stem cells, which produce melanin and are responsible for hair and skin colour. In a separate experiment, the researchers found they could prevent stress from affecting hair colour by giving the mice an anti-hypertensive, which treats high blood pressure. They were also able to identify the specific protein that causes damage to the stem cells. When this protein, cyclin-dependent kinase (CDK), was suppressed, mice that were subjected to stress did not experience the same fur colour change. It’s a breakthrough that could lead to drugs being developed which suppress CDK and delay the onset of grey/white hair.
Scientists from Cardiff University in the UK have discovered a part of our immune system that could be harnessed to kill all types of cancer. Despite their work being at an early stage, the team says the newly-discovered technique killed prostate, breast, lung and other cancers in lab tests. The findings of their research, which are published in the journal Nature Immunology, have not yet been tested in humans, but, nevertheless, the researchers say they hold “enormous potential.” The scientists made their potentially game-changing discovery while looking for “unconventional” ways the immune system naturally attacks tumours. They found a T-cell in blood that could find and kill a wide range of cancers, while leaving normal tissues untouched. Speaking about their findings, researcher Prof Andrew Sewell said: “It raises the prospect of a 'one-size-fits-all' cancer treatment, a single type of T-cell that could be capable of destroying many different types of cancers across the population.” While T-cell cancer therapies are nothing new, with treatments like CAR-T already being used to seek out and destroy cancer, the Cardiff researchers’ discovery is exciting because it could lead to treatments being developed that are more effective against solid cancers (those that form tumours). The researchers say their discovery has the potential to lead to a "universal" cancer treatment.
Sleep apnoea is a disorder that causes some individuals to experience pauses in their breathing while they are sleeping, resulting in them gasping for breath. Said pauses can last anywhere from a few seconds right up to a few minutes. But while sleep apnoea can be alleviated with certain measures, including wearing oral appliances at bedtime, its exact cause has remained open to debate. Now, a new study has revealed that having a fatty tongue could play a part. According to the research by a team from the Perelman School of Medicine in Philadelphia, larger, fattier tongues – which are more common among obese individuals – could be a main driver of sleep apnoea. That’s why when overweight and obese people shed the pounds, including fat in their tongues, any sleep apnoea they’ve been experiencing also tends to improve. “You talk, eat and breathe with your tongue - so why is fat deposited there?" said study author Dr Richard Schwab, of Perelman School of Medicine. “It's not clear why - it could be genetic or environmental - but the less fat there is, the less likely the tongue is to collapse during sleep.” The researchers now plan to discover which low-fat diets (if any) are particularly good at reducing fat in the tongue.
While it’s not possible or practical for everyone, training for and completing a marathon significantly improves the health of a new runner’s arteries, a study suggests. For the study, researchers from Barts and University College London analysed 138 novice runners attempting the London Marathon. Following six months of training, the runners’ arteries were seen to regain some youthful elasticity, something which should reduce the risk of heart attacks and strokes. Furthermore, the runners’ blood pressure fell by as much as if they had been prescribed medication. Interestingly, those who were the least fit before the training appeared to afford the most health benefits. The best news is that the British Heart Foundation (BHF), which funded the study, says smaller amounts of aerobic exercise are likely to have a similar effect, meaning people don’t necessarily need to train for a marathon to benefit. Speaking about the findings of the study, Prof Metin Avkiran, an Associate Medical Director at the BHF, said: “The benefits of exercise are undeniable. Keeping active reduces your risk of having a heart attack or stroke and cuts your chances of an early death.” According to NHS England guidelines, every week, adults should do a minimum of either: 150 minutes moderate-intensity exercise, such as brisk walking, doubles tennis or cycling 75 minutes vigorous exercise, such as running, football or rugby It’s also important to do strengthening activities - such as push-ups, sit-ups or lifting and carrying - at least twice a week.
It’s now 2020, the start of a New Year, and for many people that means following a set of resolutions, one of the most common of which will be to lose weight over the next 12 months. But if you’re keen to shed some pounds in 2020, don’t try to do it using fad diets because they don’t work and can even be harmful, says NHS England’s top doctor. Speaking about diet pills, "tea-toxes" and appetite suppressant products, Prof Stephen Powis, NHS medical director, said they are not quick fixes. Furthermore, they can even cause side effects, such as diarrhea and heart issues, he added. How to spot a fad diet? Well, according to the British Dietetic Association (BDA), any diet that promises rapid weight loss of more than 2lbs (0.9kg) of body fat a week should be viewed with caution. If it sounds too good to be true, then it more than likely is – despite any celebrity recommendations it might have. The best way to get in shape safely is through sensible eating and regular exercise. Professor Powis also warned the public against using so-called ‘party drips’ as quick fix hangover cures. These nutrient therapy IV drips are usually made up of saline solution, magnesium, calcium, B vitamins and vitamin C. But some individuals can react badly to them and, in the most serious cases, death can occur due to a toxic overdose.
Artificial Intelligence is better at diagnosing breast cancer than human doctors. That’s the conclusion of a new study published in the journal Nature. For the research, an international team, including representatives from Google Health and Imperial College London, used anonymous X-ray images of 29,000 women to train a computer model so that it could spot breast cancer. When put to the test against six radiologists in reading mammograms, the algorithm came out on top. In fact, it was even proven to be as good as two doctors working together – the current system for assessing mammograms. And unlike the human experts who had access to the patients’ medical history, the AI had just the X-rays to go on. Specifically, the AI resulted in a reduction of 1.2% in false positives - when a mammogram is incorrectly diagnosed as abnormal – and a 2.7% reduction in false negatives, where a cancer is missed. While we’re not likely to see AI being used to diagnose or clear breast cancer patients any time soon, the technology could be used to assist radiologists and speed up diagnoses going forward. Speaking about the findings of the research, Dominic King, from Google Health, said: “Our team is really proud of these research findings, which suggest that we are on our way to developing a tool that can help clinicians spot breast cancer with greater accuracy.”
A British woman has become the first in the world to receive a revolutionary new cancer therapy which involves injecting a high dose of chemotherapy directly into cancer cells. Karen Childs, from north-west London, is the first patient on the clinical trial for acoustic cluster therapy to treat cancer that has spread to her liver. During the therapy, clusters of microdroplets and microbubbles are injected into the patient at the same time as chemotherapy, which experts say will enhance its delivery. Ultrasound scans are then used to ensure the clusters “pump” the drug directly into the tumour, which should result in substantially more chemotherapy reaching cancer cells. Experts hope the technique will mean fewer doses of chemotherapy for cancer patients going forward, which should reduce side-effects. The new treatment is being trialled by the Institute of Cancer Research (ICR) and the Royal Marsden NHS Foundation Trust in London. Ms Childs, who was diagnosed with cancer in November 2013, said: “I’m not sure it’s sunk in yet that I’m the very first patient in the world to be receiving this new treatment. This trial is an exciting step for the hospital and a huge step for patients like me.” The aim of the clinical trial at this stage is to establish if the new therapy is safe and to provide data on its effectiveness. Eventually, it is hoped the treatment could be used to reduce the size of tumours prior to surgery, making them easier to remove and potentially offering more patients a cure.
The hormone oestrogen fuels the growth of many different types of breast cancer. And to reduce a woman’s risk of developing the disease, a drug called anastrozole is often used to block oestrogen production in post-menopausal ladies. But now new research has revealed that anastrozole actually continues to work long after a woman has stopped taking it. According to the research by a team at the Queen Mary University of London, the findings of which are published in The Lancet, anastrozole continues to reduce a woman’s cancer risk by 49% even seven years after they stop taking it. This is in addition to it halving a woman’s risk during the five years they take the drug. In other words, the benefits of taking anastrozole continue after treatment has stopped. Trials are now focussing on whether anastrozole can be used to prevent the onslaught of breast cancer and not just used once a woman has developed the disease. Speaking about the findings of the research, Prof Charles Swanton, Cancer Research UK's chief clinician, said: “Up until now we only knew that tamoxifen has long-lasting benefits, so it's reassuring that this study looking specifically at anastrozole, which has fewer long-term side-effects, gives better protection to women years after they stopped taking the drug.” Anastrozole is currently available on the NHS in England, but only about 10% of women who should be taking the drug actually are.
Experts say that food label warnings about the amount of physical exercise needed to burn off the calories contained in the product work. According to the researchers from Loughborough University in the UK, who looked at 14 separate studies to reach their conclusions, a simple label advising the consumer that it would take four hours to walk off the calories contained in a pizza, or 22 minutes of running to burn off a chocolate bar are effective in making people think twice about purchasing certain foods. They say the labels help people indulge less and could encourage healthier eating habits to fight obesity. Right now, it is estimated that two-thirds of the UK adult population are overweight or obese. Publishing their findings in the Journal of Epidemiology and Community Health, the researchers say this simple type of labelling could help cut about 200 calories from a person's daily average intake. The reason it works is because people don’t really appreciate calories when they see them as just numbers. But by elaborating and highlighting how much exercise is needed to burn off a particular food product, the consumer is able to make a much more informed decision. Lead researcher Prof Amanda Daley said: “We know that the public routinely underestimate the number of calories that are in foods. So if you buy a chocolate muffin and it contains 500 calories, for example, then that's about 50 minutes of running.”
While it’s been known for quite some time that increased exposure to ultraviolet (UV) rays increases a person’s chances of developing skin cancer, no link has ever been found between precipitation and cancer risk, until now… A new study has revealed a potential link between living in cold, wet regions and increased cancer prevalence. The study, the results of which are published in the journal Environmental Engineering Science, is the first in the United States to check if a relationship exists between cancer rates, precipitation, and climate zone. To find out, the scientists collated data on breast cancer, colorectal cancer, lung cancer, ovarian cancer, and prostate cancer. They also used county-level data relating to cancer incidence, climate, and demographics. Having adjusted for age, gender, ethnicity, income level, population age, and diversity, the scientists identified a strong association between increased precipitation and an increase in incidence of all cancers. While it is important to note that not all cancer types were included in the analysis, the findings are still significant and strongly suggest climate zone is a risk factor for many cancers.
So-called ‘Mediterranean diets’ have long been associated with various health benefits. And now new research suggests extra virgin olive oil – a common component of many Mediterranean diets – may protect against certain dementias. The research in mice revealed that a diet rich in extra virgin olive oil helps prevent a toxic accumulation of the protein tau, which is a hallmark of conditions such as Alzheimer’s disease. For the research, Dr. Domenico Praticò, a professor in the Departments of Pharmacology and Microbiology and the Center for Translational Medicine at the Lewis Katz School of Medicine at Temple University in Philadelphia, led a team to study the neurological benefits of extra virgin olive oil. During the study, the team looked at the olive oil's effect on "tauopathies." - age-related neurodegenerative disorders characterized by the deposition of abnormal tau protein in the brain – which can lead to the onset of various forms of dementia. They found that olive oil consumption led to 60% less tau and better cognitive recognition memory performance. “These results strengthen the [healthful] benefits of [extra virgin olive oil] and further support the therapeutic potential of this natural product not only for [Alzheimer's disease] but also for primary tauopathies,” said Dr. Praticò. The team’s findings are published in the journal Aging Cell.
New research suggests cancer patients are at higher risk of dying from cardiovascular disease than the general population. According to the study, the results of which are published in the European Heart Journal, more than one in 10 cancer survivors die from heart and blood vessel problems, rather than their initial illness. Among the 3,234,256 cancer patients studied for the research, 38% died from cancer, while 11% died from cardiovascular diseases. Among the deaths from cardiovascular diseases, 76% were due to heart disease. The risk of dying from cardiovascular disease was also highest in the first year after a patient’s cancer diagnosis and among patients younger than 35. Among those cancer patients diagnosed before the age of 55 and who went on to survive their illness, the risk of dying from cardiovascular disease was more than 10 times higher than that for the general population. Meanwhile, patients with breast, prostate or bladder cancer were most likely to die from heart disease – but this is simply because these are the most common types of cancer. It is still unclear as to why cancer patients have a seemingly higher risk of heart disease, but their treatment itself or lifestyle factors, such as being overweight, drinking too much and not exercising, could be to blame, experts say.
Older women who sleep for 5 hours a night or less are more likely to have lower bone mineral density (BMD) and osteoporosis, a new study has found. Conducted by a team from the University at Buffalo, NY, the study involved 11,084 postmenopausal women, all of who were participants in the Women's Health Initiative. It found that poor sleep may negatively affect bone health. Specifically, the team found that compared with women who got more sleep, those who reported getting only up to 5 hours of sleep per night had significantly lower values in four measures of BMD: the whole body, the hip, the neck, and the spine. The lower BMD measures of the group getting less sleep were the equivalent of them being one year older than their peers in the more sleep group. Now one explanation for why these results were seen is due to how our bodies remove old bone tissue and replace it with new bone tissue, a process known as bone remodeling. “If you are sleeping less, one possible explanation is that bone remodeling isn't happening properly,” said lead study author Heather M. Ochs-Balcom, Ph.D., an associate professor of epidemiology and environmental health at the University at Buffalo School of Public Health and Health Professions. The full findings of the study are published in a paper in the Journal of Bone and Mineral Research.
Penicillin was discovered by chance in 1928 when Alexander Fleming noticed it had powerful antibacterial properties. Fast forward to the 1940s and penicillin was being commonly used in the fight against deadly infections. But penicillin is not for everyone and some people are allergic to the popular antibiotic. If someone has ever had a reaction to the drug, their medical records usually contain a note of this “fact”. However, new research suggests that many people who believe they are allergic to penicillin may have outgrown their allergy, or they may not have been allergic in the first place. In fact, the research shows that as many as nine in 10 people who think they are allergic to penicillin may not be. Speaking at the ACAAI Annual Scientific Meeting 2019 in Houston, TX, the researchers added that some patient’s penicillin allergies remain on their medical records even if they test negative later in life. “Our study found that of the 52 patients who tested negative to penicillin and were interviewed, 98% understood they were not allergic to penicillin,” said lead author, Dr. Sonam Sani, an allergist, immunologist, and fellow of the ACAAI. “Of those, 29% still had a penicillin allergy label in their electronic medical record, and 24% still carried the label in their pharmacy records,” she added. The research is important because it highlights just how easy it is for someone to assume they have a penicillin allergy when, in fact, they don’t. Many penicillin alternatives are more expensive, have lower efficacy, and risk boosting antibiotic resistance.
New research suggests that some people have an inherent dislike of certain vegetables. According to the study by Dr Jennifer Smith and colleagues from the University of Kentucky School of Medicine, inheriting two copies of the unpleasant taste gene provides a "ruin-your-day level of bitterness" to foods such as broccoli and sprouts. The research could explain why some people find it really difficult to include certain vegetables in their diets. The team’s findings could also provide some explanation as to why beer, coffee and dark chocolate taste unpleasant to some people. Everyone inherits two copies of a taste gene called TAS2R38, which basically allows us to taste bitterness. However, people can inherit different variants. People who inherit a variant called AVI aren't sensitive at all to bitter tastes. Those who inherit one copy of AVI and another called PAV do experience bitter tastes, but not to extremes. That super-sensitivity for bitter foods is found in people who inherit two copies of the PAV variant - often called "super-tasters". Of the 175 people studied, those with two copies of the bitter taste PAV gene variant ate only small amounts of leafy green vegetables. Speaking to medics at a meeting of the American Heart Association, Dr Smith said: “You have to consider how things taste if you really want your patient to follow nutrition guidelines”.
A compound found only in avocados could help reduce type 2 diabetes, new research suggests. The study by researchers from the University of Guelph in Canada found that a fat molecule called avocatin B, or AvoB - which avocados alone contain – can help strengthen insulin sensitivity and could forestall type 2 diabetes. Initial tests involving mice showed that AvoB slowed weight gain and increased insulin sensitivity by ensuring the complete oxidation of fats. As a result, mice that were given the compound had improved glucose tolerance and utilization. Then, in a separate, double-blind placebo‐controlled human trial, an AvoB supplement was given to people with an average Western diet for 60 days. The researchers found that the participants had tolerated the compound well and no negative effects in the liver, muscles, or kidneys were witnessed. There was also some weight loss among participants that took the supplement, though the authors of the study considered it statistically insignificant. Paul Spagnuolo, Ph.D., an associate professor at the University of Guelph, said the research team will now design clinical trials to assess AvoB's effectiveness in people. Furthermore, they have already received clearance from Health Canada to sell AvoB in powder and pill forms, perhaps as early as next year.
Le diagnostic précoce est l'un des facteurs clés dans la prévention et le diagnostic d'un grand nombre de maladies qui ne présentent pourtant aucun symptôme apparent chez le patient. Les bilans des santé proposés par notre partenaire espagnol, Quironsalud, se focalisent sur une exploration complète, multidisciplinaire et personnalisée, adaptée au sexe, âge et antécédents personnels du patient. A quel moment faut-il faire un check-up ? Des examens médicaux réguliers sont recommandés pour tous ceux qui veulent prendre en main leur santé et pour qui la détection des facteurs de risque dans les meilleurs délais est une priorité. Chez Quironsalud, en une journée, vous pourrez suivre un bilan de santé complet grâce à une coordination et un parcours de soins conçu spécifiquement à cet effet, pour le confort du patient et de son entourage. Les bilans de santé proposés par Quironsalud s’adressent à chacun d’entre nous. Que vous soyez en bonne santé, que vous souffriez d’une maladie chronique ou que vous présentiez certains symptômes bien spécifiques, les équipes médicales des établissements de santé QuironSalud sauront vous proposer le bilan personnalisé adapté à vos besoins. Dans cas, comme par exemple pour des patients souffrant de cancer ou de maladies cardiovasculaires, un contrôle périodique peut vous être proposé pour vous permettre de suivre au plus près l'évolution ou la rémission de votre pathologie. Si vous adoptez le programme patient international proposé par le groupe QuironSalud, tout sera mis en œuvre pour faciliter l’organisation de vos consultations, y compris, l’aide à la planification du voyage, facilitation pour l’obtention du visa, prise en charge à l'aéroport/gare et le transfert à la clinique ou à votre hôtel. Un service de traduction est à aussi à votre disposition ainsi qu'un accompagnateur qui sera à votre écoute tout au long de votre séjour au centre médical Quironsalud. Pour plus d'informations, contactez-nous dès maintenant au : firstname.lastname@example.org ou par téléphone au +33 953 02 03 09.
An innovative new blood test can detect breast cancer up to 5 years before symptoms appear, researchers say. Developed by a team at the University of Nottingham, England, the new blood test identifies specific immune system ‘autoantibodies’, which are produced when tumor-associated antigens (TAAs) are present – like those produced by breast cancer cells. While the test is still only partially effective, it could eventually provide the best chance of detecting breast cancer early, enabling faster treatment and a greater chance of success. In the pilot study, the researchers took blood samples from 90 breast cancer patients when they were diagnosed with breast cancer. They then matched these samples with ones from 90 patients without breast cancer. Then, they used a technology called protein microarray to test the blood samples for the presence of autoantibodies and 40 TAAs associated with breast cancer, plus another 27 TAAs that were not known to be linked with the disease). The researchers used a technology called protein microarray to rapidly test the blood samples for autoantibodies against 40 TAAs associated with breast cancer, plus another 27 TAAs that were not known to be linked with the disease. Speaking last Sunday at the U.K. National Cancer Research Institute conference in Glasgow, Scotland, researcher Daniyah Alfattani, a Ph.D. student at the University of Nottingham's Centre of Excellence for Autoimmunity in Cancer (CEAC), said: “The results of our study showed that breast cancer does induce autoantibodies against panels of specific tumor-associated antigens. We were able to detect cancer with reasonable accuracy by identifying these autoantibodies in the blood.” At present, annual mammograms are the best way for doctors to detect the presence of breast cancer while in its early stages.
Type 2 diabetes is a chronic condition that occurs when a person’s body ineffectively uses insulin. It is the most common form of diabetes, accounting for 90% to 95% of the more than 30 million diabetes cases in America today. Despite rising numbers, it is estimated that around 80% of new type 2 diabetes diagnoses could be prevented with lifestyle changes and more education. But while it’s been known for some time that when added to a genetic predisposition, factors like being overweight and a lack of physical activity increase a person’s risk of developing type 2 diabetes, very little research has been done to determine the impact of other environmental factors. That’s why a new study by a team from the University of Illinois at Chicago (UIC) School of Public Health which set out to determine if type 2 diabetes risk changes between urban and rural environments is interesting. According to the research - which involved examining 3,134 people across the United States - the quality of the air, water, and land, as well as numerous sociodemographic factors, such as education, average household income, violent crime rates, or property crime rates has an impact on a person’s type 2 diabetes risk. So-called ‘built domain factors’ were also used. These included how many fast-food restaurants were in a particular area; how many fatal accidents occurred, and how many highways, roadways, or public housing units there were. The research found that a poorer environmental quality was linked with a higher prevalence of type 2 diabetes. Specifically, inferior air quality and built and sociodemographic factors were associated with a higher risk of diabetes in rural areas, while in urban areas, only air and sociodemographic factors were associated with diabetes risk. “There might be something happening in rural areas that is different than in urban areas. Our findings suggest that environmental exposures may be a bigger factor in rural counties than in urban areas in the U.S.,” explains Dr. Jyotsna Jagai, lead author.
Obesity is worryingly common across the world today. World Health Organization statistics from 2018 show that global obesity has almost tripled since 1975 and most of the world’s population now live in a country where being overweight or obese kills more people than being underweight. But while obesity is known to increase a person’s risk of certain health conditions, new research has revealed that it does not seemingly affect men and women in the same way. According to the study from Oxford University in the United Kingdom, the findings of which are summarized in the journal PLOS Genetics, the risks of developing different health problems as a result of being obese are different for men and women. For example, obese women are at higher risk of developing type-2 diabetes than men. Meanwhile, obese men have a higher risk of chronic kidney disease and chronic obstructive pulmonary disease. The team says their findings add to the existing evidence that preventing and treating obesity is a crucial step in countering the emergence of other health conditions. “This study shows just how harmful carrying excess weight can be to human health, and that women and men may experience different diseases as a result,” said first author Dr. Jenny Censin. For the study, the team from Oxford University analyzed genetic information and three different obesity measures in a cohort of 195,041 men and 228,466 women.
In vitro fertilization (IVF) is one of several techniques that can be used to help people with fertility problems have a baby. With IVF, an egg is removed from the woman’s body and fertilized with sperm in a laboratory. The fertilized egg – known as an embryo – is then placed inside the woman’s womb where it will hopefully implant in the lining of her uterus and grow and develop. IVF can be carried out using a woman’s eggs and her partner’s sperm, or eggs and sperm from donors. There are seven main stages associated with IVF treatment: Ovary stimulation – Medication is used to encourage the woman’s ovaries to produce more eggs than usual. Progress monitoring and maturing of eggs – Ultrasounds and blood tests are used to monitor the eggs, while medication is administered to help them develop. Egg retrieval – A needle is used to collect eggs from each ovary. This step takes around 30 minutes and the woman can usually go home afterwards. Egg fertilization – The retrieved eggs are mixed with sperm. They have the chance to find each other and fertilize the same as they would inside the body. Embryo development – If the sperm fertilizes the egg, it becomes an embryo. The embryo is then placed inside a special incubator where conditions are perfect to encourage growth and development. Embryo transplant – Once the IVF specialists are satisfied that the embryo is developing correctly, it is then transplanted into the woman’s uterus. Final blood test – Approximately two weeks after the embryo has been transplanted, a final blood test is performed to check the woman’s hCG (human chorionic gonadotropin) levels, which are used to determine if she is pregnant or not. It is important to note that not all eggs, unfortunately, will fertilize and reach the embryo stage. This can occur as a result of immature eggs and/or weak sperm. If you and your partner have been struggling to conceive naturally, IVF could help you get pregnant. Find out more about how we can facilitate IVF treatment for French-speaking patients in Spain by contacting us today.
People who take daily blood pressure medication should take it just before bedtime to get the most out of it, researchers say. Writing in the European Heart Journal, the researchers say that while it may sound like a very simple tip, it’s one that could save lives. The reason why taking such medication at bedtime is more beneficial is because our body clocks alter the way our bodies respond to it. At night, our blood pressure is typically lower than it is during the day. However, if for some reason our blood pressure does not dip and remains consistently high, our chances of having a stroke or heart attack significantly increase. The study found that patients who took their daily blood pressure medication before bedtime had significantly lower average blood pressure both at night and during the day than those who took their medication in the morning. Their blood pressure also dipped more at night. Lead researcher Prof Ramon Hermida, from the University of Vigo in Spain, said doctors should consider recommending their patients take their daily blood pressure medication at night going forward – especially as it’s “totally cost-free. It might save a lot of lives. “Current guidelines on the treatment of hypertension do not recommend any preferred treatment time. Morning ingestion has been the most common recommendation by physicians based on the misleading goal of reducing morning blood pressure levels. “The results of this study show that patients who routinely take their anti-hypertensive medication at bedtime, as opposed to when they wake up, have better-controlled blood pressure and, most importantly, a significantly decreased risk of death or illness from heart and blood vessel problems.” The next step is to determine whether the findings of the study apply to different brands of blood pressure medication. Lifestyle factors that have an impact on blood pressure: Smoking Drinking too much alcohol Being overweight Not doing enough exercise Eating too much salt
Researchers have found fat in overweight and obese people’s lungs. It’s the first time such a discovery has been made and could provide important clues as to why overweight and obese people have an increased risk of asthma. For the research, a team from Australia analysed lung samples from 52 deceased individuals. They found the amount of fat present increased in line with Body Mass Index (BMI). Being overweight/obese is already linked to having asthma, but it was previously thought that excess weight pressing on the lungs was the main reason for this. However, the Australian researchers say fatty tissue in the walls of airways takes up space and causes inflammation, which can lead to wheezing and asthma. Speaking about the findings of the research, which are published in the European Respiratory Journal, Dr Peter Noble from the University of Western Australia said: “We’ve found that excess fat accumulates in the airway walls where it takes up space and seems to increase inflammation within the lungs. “We think this is causing a thickening of the airways that limits the flow of air in and out of the lungs, and that could at least partly explain an increase in asthma symptoms.” Experts say that more research is now needed to find out whether the build-up of fatty tissue could be reversed through weight loss. In the meantime, asthma patients should be supported to achieve a healthy weight.
Tiny microphones could provide invaluable insights into a person’s knee health, a new study suggests. According to researchers, arthritic knees are ‘noisy’ and emit telltale sounds - but sounds that can only be heard by microphones. The waveforms emitted by the noisy knees can then be analysed by computers to provide insights into the health of the knee. The researchers say the technology – similar to the kind used by engineers to listen for faults in bridges - can be used to better diagnose conditions like osteoarthritis and help develop better treatments as a result. For the study - conducted by a team from Lancaster University, the University of Central Lancashire and Manchester University – patients with osteoarthritis were asked to stand up and down five times, while acoustic signals from their knees were captured by the microphones. The theory behind the trial is that knees which are functioning normally should act like smooth and well-lubricated engineering structures, emitting very little in the way of noise. In comparison, rough and poorly-lubricated surfaces (arthritic knees) would generate acoustic signals. The trial found that the microphone technique could distinguish between the two different types of knee, thus offering a solution that did not involve an X-ray. Publishing its findings in the journal PLOS ONE, the research team said the more noisy the knee, the more severe the osteoarthritis. However, they did admit that more research and larger-scale trials are needed so the technique can be developed further.
A cost effective and widely available drug could help save hundreds of thousands of lives each year if it was given to patients brought into hospitals with head injuries, a new study has found. The drug, tranexamic acid, helps stop bleeding in and around the brain, arresting damage that can occur post-trauma. It’s already approved for clinical use and is routinely taken to prevent internal bleeding in other parts of the body following trauma, as well as women with dangerous bleeding after childbirth. According to the study published in The Lancet, if given early enough, tranexamic acid can improve patient survival rates. While it cannot reverse trauma damage, it can prevent a small bleed becoming worse. The team from the London School of Hygiene and Tropical Medicine (LSHTM) tested tranexamic acid on almost 13,000 patients. They found that if given within three hours of a head trauma, the number of fatalities was reduced by as much as 20%. Furthermore, tranexamic acid is a cost effective treatment, with a course in the UK costing around £6.20 (7.09 euros) per patient. Speaking about the findings of the trial, one of the lead investigators, Prof Haleema Shakur, from the LSHTM, said: “The results are just amazing. It's the first trial to ever show that a [medical] treatment can reduce the risk of traumatic brain injury patients dying. “This is the first time that we have seen a beneficial effect. It will have huge implications worldwide. “It's a widely available drug, it's relatively cheap and it's really simple to give.”
Lycopene - a natural pigment that gives red fruits and vegetables their colour - is an antioxidant that protects against cell damage, and tomatoes contain plenty of it. In fact, it is estimated that tomatoes account for 80% of the lycopene in the US diet. Now, a new study suggests Lycopene may also help boost sperm quality. According to the research by a team at the University of Sheffield, healthy men who consumed the equivalent of two tablespoons of concentrated tomato puree each day were found to have better quality sperm. During the 12-week trial, 60 men were randomly selected to take 14mg of lactolycopene supplement each day. The reason a supplement was used is because the participants would have had to eat 2kg of tomatoes each day to obtain an equivalent dose of lycopene. The participants’ sperm was tested before, during and after the trial. While there was no difference in sperm concentration, the men who had been taking the lycopene had healthier and faster sperm. Encouraged by the results, the researchers now want to expand the trial to include more men and see if the findings are the same. Lycopene has also been previously linked to other health benefits, including a lowered risk of heart disease and certain cancers.
Male breast cancer is pretty rare. In fact, it accounts for just 1% of all breast cancer cases. That’s why very few studies have looked at what factors can lead to more positive outcomes for patients. To address this reality, researchers from Mayo Clinic in Rochester, Minnesota, have conducted one of the largest male breast cancer studies to date, the findings of which are published in the journal Cancer. The researchers found that 51% of male breast cancer diagnoses occurred between the ages of 50 and 69, and that the average age of diagnosis was 64. In fact, only 15% of the patients were diagnosed before the age of 50. Interestingly, the study authors found that black men, older patients, individuals with other ongoing health issue and those with higher tumor grade and stage had poorer prognoses. Furthermore, they found that patients who underwent a full mastectomy also had poorer outcomes. The prognosis was better for patients who lived in wealthier areas, whose tumors carried the progesterone receptor and men who received radiation therapy, chemotherapy or anti-estrogen therapy. While female breast cancer treatment has improved dramatically over the years, the study authors say it is unclear whether these advancements have been applied to the management of male breast cancer too. Two of the reasons for this are because male breast cancer usually occurs later in life and it commonly spreads to the person’s lymph nodes. The researchers hope their paper will shine some more light on this little known condition and lead to better outcomes for patients going forward.
A new study has found that if people with type-2 diabetes achieve just 10% weight loss within 5 years of being diagnosed, they are twice as likely to experience remission at the 5-year follow-up as those who haven’t lost any weight. The findings of the study by researchers from Cambridge appear in the journal Diabetic Medicine and were obtained through analysis of 867 people aged 40-69 with newly diagnosed type-2 diabetes. Having followed the study participants for 5 years, the researchers found that 257 (30%) had diabetes in remission. Speaking about their findings, first author Hajira Dambha-Miller, Ph.D. said: “Our results suggest that it may be possible to get rid of diabetes, for at least 5 years, with a more modest weight loss of 10%. This will be more motivating and hence more achievable for many people.” The fact diabetes can be sent into remission with just moderate weight loss – and not just the drastic intensive weight loss measures we’ve known about for some time - will be welcome news for many people living with the condition. It reinforces the importance of managing one’s weight through dietary choices and physical exercise. Going forward, the Cambridge team hopes to be able to use the research to help medical professionals better support patients with type-2 diabetes and reduce their symptoms.
Some species of bacteria are stripping off their outer layers in an attempt to evade antibiotics and survive. It’s a reality that could explain why some infections keep coming back. According to researchers at Newcastle University in the UK, the bacteria are “undressing” and removing their cell walls – the very part of them that some antibiotics target. The cell walls of some bacteria are made from sugars and amino acids. While they give the bacteria shape and protection, these walls provide a weak spot that can be exploited by antibiotics. Penicillin, the first antibiotic to be discovered and the most widely used in the world, works by disrupting the cell wall and causing the bacteria to burst. The study, which is published in the journal Nature Communications, found that bacteria associated with recurring urinary tract infections in elderly patients slipped out of their cell walls to avoid the effect of the antibiotics. It’s the first time that research has shown bacteria using this method to survive antibiotic treatment and while not all survive – most get taken care of by the body’s immune system - it does offer some explanation as to why certain infections come back again and again. The discovery could pave the way for new treatments to be developed, including combination therapies that target both the bacteria’s cell wall and inner workings.
Gum disease is linked to an increased risk of hypertension, a new study has found. Furthermore, the more sever the gum disease, the greater a person’s risk of high blood pressure. The research by University College London's Eastman Dental Institute – the findings of which appear in the journal Cardiovascular Research – shows people with periodontitis (an advanced form of gum disease) have a higher risk of hypertension. Hypertension, according to the Centers for Disease Control and Prevention (CDC), affects 32% of all American adults, and as many as 47.2% of people aged over 30 have some form of gum disease, which is why the new research is so intriguing. While the two conditions may appear to be completely unrelated, the new research shows otherwise. And when you consider that high blood pressure is the leading cause of premature death worldwide, affecting up to 45% of adults, the findings of the study could result in much more attention being paid to combatting gum disease going forward. Specifically, the research revealed an association between moderate-to-severe periodontitis and a 22% higher risk of hypertension, Moreover, severe periodontitis was linked to a 49% higher risk of hypertension. Speaking about the findings of their research, senior author Prof. Francesco D'Aiuto, from the University College London Eastman Dental Institute in the United Kingdom, said: “Previous research suggests a connection between periodontitis and hypertension and that dental treatment might improve blood pressure, but to date, the findings are inconclusive. “Hypertension could be the driver of heart attack and stroke in patients with periodontitis,” he added.
A new tumour-agnostic drug has been approved for use in Europe. The revolutionary drug, experts say, has the potential to cure more cancer patients and reduce side-effects. Called larotrectinib, the new drug does not care where the cancer is growing in the body and instead looks for a specific genetic abnormality, which means it can be used to treat a wide range of tumours. Doctors in the UK have said the new drug is “a really exciting thing” and marks a move away from having ‘drugs that treat breast cancer’, ‘drugs that treat bowel cancer’ and ‘drugs that treat lung cancer’, to having drugs that target the genetic make-up of each patient’s tumour. However, the decision by European regulators does not mean that any cancer patient can take advantage of larotrectinib right away. Its approval for use right now only applies to patients with solid tumours that have been caused by a genetic abnormality known as an NTRK gene fusion. This rare abnormality happens when part of an individual’s DNA accidentally merges with another, leading to an alteration in the body’s blueprint that allows cancer to grow. Speaking about the drug development, Dr Julia Chisholm, a children's cancer consultant at the Royal Marsden Hospital in London, said: “It is a really exciting thing, as is it works across a range of cancers. It's not confined to one.”
The method via which a baby is born has a dramatic impact on its gut bacteria and could explain why babies born by Caesarean section are more likely to experience health problems later in life, a new study has found. The study by Wellcome Sanger Institute, UCL, and the University of Birmingham – the largest of its kind – looked at babies’ microbiomes (the bacteria, viruses and fungi that live in our guts) to see if they formed differently depending on how a baby was born. For the research, samples were taken on a regular basis from the nappies of 600 babies in their first month of life. The results showed that vaginally born babies got most of their first bacteria from their mothers. However, babies born via Caesarean section showed high levels of hospital bugs, with some having as much as 30% of their total microbiomes made up by such bugs. It’s a reality that could explain why babies born by Caesarean section are more susceptible to certain conditions when they are older, like allergies, asthma and type 1 diabetes. Speaking about the findings of the research, Dr Trevor Lawley, from the Wellcome Sanger Institute, said: “What surprised me and scared me was the amount of healthcare bugs showing up in these children. “But what excites me is we have an amazing body of data now that we can build on, to think about how to properly establish the human ecosystem, starting at birth.”
A team of international scientists has discovered that a drug usually used to treat enlarged prostates may be beneficial in the fight against Parkinson’s disease. The drug, Terazosin, helps ease the discomfort associated with an enlarged prostate (benign prostatic hyperplasia, or BPH) by relaxing muscles in the prostate and part of the bladder. This helps relieve symptoms like difficulty in beginning to urinate and needing to urinate frequently or urgently. Now, researchers believe it may also help slow the progression of Parkinson’s by protecting brain cells from being damaged – something that is not possible at present. For the research, the team of scientists studied thousands of patients with both BPH and Parkinson's disease. They found that Terazosin boosted energy production in brain cells and slow neurodegeneration. It does this by activating an enzyme called PGK1. Publishing their findings online in the Journal of Clinical Investigation, the scientists said that while it was too premature to talk about a cure for Parkinson’s, their research was ‘exciting’ and could have the potential to change the lives of people with Parkinson’s disease going forward. Because Terazosin is already approved for use in patients with enlarged prostates, getting it repurposed as a Parkinson’s drug also shouldn’t be a problem.
A new way of cooling human livers could significantly extend the time they can be kept ahead of an organ transplant By supercooling livers to -4C, researchers have been able to triple their viable lifespan to more than one day. It could revolutionise the way organs are stored in the future and allow even more people to benefit from transplants. The team from Massachusetts General Hospital and Harvard Medical School pioneered the technology using rats’ livers five years ago. The tiny livers were supercooled, while nutrients and oxygen were pumped around their blood vessels. But developing the technique to work with human organs wasn’t without its challenges. Because they are much larger, human livers are at greater risk of ice crystals forming, which can rupture cells and kill tissue. To overcome this, the researchers used protective agents to prevent the livers from freezing. As a result, they were able to extend their viable lifespans to 27 hours – a significant increase on the current nine hours when organs are stored on ice. Once brought back up to temperature, the livers were found to function normally and also responded as expected when connected to an artificial blood supply. One of the researchers, Dr Reinier de Vries, said: “This is a big breakthrough in organ preservation. “This is the first time that we actually show that it is feasible to preserve human organs at sub-zero temperatures.”
Simple educational and motivational text messages can help people with diabetes manage their blood sugar better, a new study has found. It is not only an extremely affordable and scalable measure, but one that can be applied globally. According to the six-month Chinese study, diabetes patients who received the text messages and standard care reduced their glycated hemoglobin (HbA1c ) by more than patients who just received standard care. The results showed an average reduction in HbA1c of 2 mmol/mol (0.2%) in patients who received the supportive text messages. The group that did not receive the text messages experienced an average increase in HbA1c of 1 moll/mol (0.1%). For the study, the participants were split into two groups: one that received standard diabetes care and two text messages each month thanking them for their participation, and another group that received standard care and up to six text messages per week containing information on subjects like dietary advice, physical activity, emotional support and blood glucose monitoring. As well as actually reducing their HbA1c, the group receiving the supportive text messages also had a greater proportion of patients who achieved their HbA1C target of less than 7% (69.3% vs. 52.6% in the control group). Speaking about the findings of the study, Dr Xiqian Huo, of Beijing's Fuwai Hospital, said: “Lifestyle advice such as strict dietary control may have contributed to glycemic improvements, together with reminders to monitor blood glucose regularly. The messages were designed to provide information and motivation, and help patients set goals and manage stress.” The results of the study were presented at the annual meeting of the European Society of Cardiology on Saturday, August 31 also appear in journal Circulation: Cardiovascular Quality and Outcomes.
Cancer has surpassed cardiovascular disease as the biggest killer of middle-aged people in higher-income nations, a study suggests. Globally, stroke and heart problems are the leading causes of death among this age group. But the findings of this latest research led by a team from Canada's McMaster University shows that middle-aged people in rich nations are 2.5 times more likely to die of cancer than cardiovascular disease. In contrast, people in poor countries are three times more likely to die from cardiovascular disease. The study, published in The Lancet, is drawn from a global research program, the Prospective Urban and Rural Epidemiologic (PURE) study, involving 160,000 people from 21 different countries. While cardiovascular disease accounted for more than 40% of deaths in middle- and low-income countries, it only accounted for less than a quarter in richer nations. The researchers say this could be due to people living in richer countries receiving more medication and support. Speaking about the findings of the research, Gilles Dagenais, a professor at Quebec’s Laval University in Canada who co-led the work, said: “Our report found cancer to be the second most common cause of death globally in 2017, accounting for 26% of all deaths. But as (heart disease) rates continue to fall, cancer could likely become the leading cause of death worldwide, within just a few decades.”
Drinking red wine (in moderation) could be good for your gut, according to researchers from the UK. The team from King’s College London says red wine contains compounds that help increase the number of different types of bacteria that live in the gut. The micronutrients, known as polyphenols, are more abundant in red wine vs. beer, cider and white wine, and act as fuel for microbes living inside the bowel. Polyphenols are found in many fruits and vegetables, including the grapes used to make red wine. The researchers say even just one glass of red wine a fortnight can make a difference, but warn that their findings should not be used as an excuse to binge drink. Publishing its research in the journal Gastroenterology, the team said the “friendly” bugs in our gut help keep us healthy. Even small changes in our gut microbiota – the community of bugs that live there – can make us more susceptible to conditions like obesity, heart disease and Irritable Bowel Syndrome. The gut microbiota of people who drink red wine was found to be more diverse than that of those who do not drink wine. Furthermore, the more wed wine consumed, the greater the levels of diversity – although it’s important to note that nobody involved in the trial was a heavy drinker. Speaking about the findings of their research, Dr Caroline Le Roy said: “If you must choose one alcoholic drink today, red wine is the one to pick as it seems to potentially exert a beneficial effect on you and your gut microbes, which in turn may also help weight and risk of heart disease.”
A pill that contains four different medicines and is designed to be taken daily could dramatically reduce the number of heart attacks and strokes, a new study has found. The polypill – which is the generic term used to describe a medication that contains multiple active pharmaceutical ingredients – contains aspirin, a cholesterol-lowering statin and two drugs to reduce blood pressure. For the study, researchers from Iran and the UK studied around 6,800 people from more than 100 villages in Iran. Half were given the polypill and advice on how to improve their health through lifestyle changes and the other half were just given the lifestyle changes advice. After five years, the group taking the polypill had experienced 202 cardiovascular events, while the group that had just been given the advice had experienced 301 cardiovascular events. In other words, the group taking the polypill had experienced around a third less cardiovascular events. The researchers say the pill costs just pennies a day, but could have a huge impact, especially in poorer countries where doctors have fewer options available to them. Stroke and coronary heart disease are the top two causes of death worldwide, killing more than 15 million people each year. Obesity, smoking and doing little exercise are all risk factors associated with an unhealthy heart. Based on the findings of the study, if 35 people were all given the polypill daily, it would prevent one of them developing a major heart problem within 5 years. “Given the polypill's affordability, there is considerable potential to improve cardiovascular health and to prevent the world's leading cause of death,” said Dr Nizal Sarrafzadegan, of Isfahan University of Medical Sciences, Iran. The findings of the research are published in The Lancet.
Having high blood pressure before middle age may pose a risk to brain health in later life. According to a new study, the results of which are published in The Lancet Neurology, the “window of opportunity” to safeguard brain health runs from the mid-30s to the early-50s. And having high blood pressure in the 30s and 40s could lead to blood vessel damage and brain shrinkage. For the study, a team of researchers from UCL Queen Square Institute of Neurology followed 500 people born in 1946. Throughout the study, participants had their blood pressure measured and had brain scans. The researchers found that blood pressure increases between the ages of 36 and 43 were linked to brain shrinkage. Moreover, blood pressure increases between 43 and 53 were associated with blood vessel damage or “mini strokes” when people reach their 70s. Speaking about the findings of the research, Dr Carol Routledge, director of research at Alzheimer's Research UK, said: “High blood pressure in midlife is one of the strongest lifestyle risk factors for dementia, and one that is in our control to easily monitor and manage. “Research is already suggesting that more aggressive treatment of high blood pressure in recent years could be improving the brain health of today's older generations. “We must continue to build on this insight by detecting and managing high blood pressure even for those in early midlife.”
People with type-2 diabetes get no benefit from taking omega-3 fish oil supplements, a new study has found. According to researchers from the University of East Anglia, while omega-3 supplements are not harmful for people with type-2 diabetes (this has been a concern previously), they don’t provide any benefit either. This contradicts a common belief that omega-3 can protect against diabetes and even reverse the condition. The study, which involved 58,000 participants, found that people who consumed more omega-3 had the same risk of developing diabetes as individuals who did not. Furthermore, taking omega-3 fish oil did not influence levels of blood glucose, insulin and glycated haemoglobin - all measures of how the body handles sugar. ‘Better to eat fish’ Douglas Twenefour, deputy head of care at Diabetes UK, said: “Eating a healthy, varied diet is incredibly important, and we know that certain foods - including fruits, vegetables, wholegrains, yoghurt and cheese - can help to lower your risk of type 2 diabetes. “While omega-3 fatty acids are crucial for our overall health, it's generally better for people with type 2 diabetes to get their intake by eating at least two portions of oily fish a week, than by taking supplements." The advice from Dr Lee Hooper, who led the research, is to forego the expensive omega-3 supplements and instead buy oily fish and/or spend your money on physical activity, which will have more of a positive impact when it comes to type-2 diabetes.