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Coronavrius: Oxford vaccine appears safe, triggers immune response

21/07/2020

Coronavrius: Oxford vaccine appears safe, triggers immune response

A coronavirus vaccine developed by the Universality of Oxford and AstraZeneca appears safe and triggers an immune response that should protect people against infection.


According to a trial of the vaccine involving 1,077 participants, the findings of which are published in The Lancet, the vaccine led to individuals making antibodies and T-cells that fight SARS-CoV-2, the new coronavirus.


Within just 14 days of receiving the vaccine, participants’ T-cell levels peaked. After 28 days participants’ antibody levels peaked. Both T-cells and antibodies are crucial in the body’s immune defence of viruses, which is why any effective vaccine needs to induce both in the people who receive it.


But while the findings are immensely promising, more research is needed to determine exactly how safe the vaccine is, whether it can indeed provide protection against SARS-CoV-2 and how long any protection would last.


Nevertheless, the UK has already ordered 100m doses of the vaccine.


Prof Andrew Pollard, from the Oxford research group, told the BBC: “We're really pleased with the results published today as we're seeing both neutralising antibodies and T-cells.


“They're extremely promising and we believe the type of response that may be associated with protection.


“But the key question everyone wants to know is does the vaccine work, does it offer protection... and we're in a waiting game.”


The next step is for more than 10,000 people to take part in the next stage of the trial to further determine how safe the vaccine is.


[Related reading: World leaders pledge billions to help develop coronavirus vaccine]

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