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Landmark child malaria vaccine rolls out in three African countries

25/04/2019

According to the World Health Organization (WHO), in 2017, there were an estimated 219 million cases of malaria in 87 countries, which resulted in 435,000 deaths – many of which were children. It remains one of the world’s leading killers, claiming the life of a child every two minutes. That’s why a new vaccine against the deadly mosquito-borne disease is being hailed as a landmark. The first vaccine of its kind, the RTS,S vaccine trains the body’s immune system to attack the malaria parasite. It is being given to children as part of a large scale pilot programme being conducted in Malawi. Previous, smaller trials showed that nearly 40% of 5-to-17-month olds who received the RTS,S vaccine were protected from malaria. The vaccine comes at a crucial time as malaria cases appear to be rising once more after decades of success in combatting the disease. Speaking about the pilot, Dr Matshidiso Moeti, WHO Regional Director for Africa, said: “Malaria is a constant threat in the African communities where this vaccine will be given. The poorest children suffer the most and are at highest risk of death. “We know the power of vaccines to prevent killer diseases and reach children, including those who may not have immediate access to the doctors, nurses and health facilities they need to save them when severe illness comes.” Malawi is the first of three countries, along with Ghana and Kenya, where the vaccine will be rolled out. The aim is to immunize 120,000 children aged two years and below. Malawi, Ghana and Kenya were chosen because despite operating large programmes to tackle malaria, including promoting the use of mosquito nets, they still have high numbers of cases. The RTS,S vaccine has been more than three decades in the making.

Dengue fever could be culled by special mosquitoes

02/08/2018

Dengue fever is a mosquito-borne viral disease found in tropical and sub-tropical climates worldwide. Severe dengue is a leading cause of death and serious illness among children in Asian and South American countries. Unfortunately, there is no definitive medical treatment for dengue fever, but hope may be on the horizon. That’s because researchers in Australia say they have managed to eradicate dengue from an entire city using captive-bred mosquitoes. The captive-bred mosquitoes have the naturally-occurring bacteria Wolbachia, which hinders dengue transmission. The bacteria are spread as the released mosquitoes mate with local mosquitoes. As a result, the city of Townsville has been dengue-free since 2014. The researchers, all of whom are from Monash University, also believe the technique could be used to stop other mosquito-borne diseases like Zika and malaria. Speaking to the Guardian, Scott O'Neill, director of the World Mosquito Program, said: "Nothing we've got is slowing these diseases down - they are getting worse." "I think we've got something here that's going to have a significant impact and I think this study is the first indication that it's looking very promising." The results of the Australian researchers’ study were published in Gates Open Research. The next step is to trial the approach in Yogyakarta in Indonesia - a city of nearly 390,000.

Malaria breath test could provide cheaper, non-invasive diagnoses

09/11/2017

A breath test that can detect whether someone has malaria is showing signs of promise in parts of Africa where it’s being trialled. The crude prototype picks up on distinctive “breath prints” that people with the mosquito-borne disease have. During a trial involving children in Malawi, in south-eastern Africa, the breath test had a success rate of 83%. While that’s not high enough for the test to be routinely used at present, it is very promising and suggests the test could be developed further into an off-the-shelf product. According to the team of scientists at Washington University in St. Louis, Mo, who developed the breath test, individuals with malaria have six unique compounds in their breath. These compounds are what the breath test looks out for. Once refined and able to detect malaria with greater accuracy, the breath test could provide a cheaper, non-invasive method for determining whether someone has the disease. Talking about the promising signs displayed by the breath test, Prof James Logan from the London School of Hygiene and Tropical Medicine said: "The rapid detection of asymptomatic malaria is a challenge for malaria control and will be essential as we move towards achieving the goal of malaria elimination. A new diagnostic tool, based on the detection of volatiles associated with malaria infection is exciting." According to the Centers for Disease Control, about 212 million cases of malaria were reported worldwide in 2015 and about 429,000 people died, many of them children.

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