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‘Spectacular’ results seen in prostate cancer immunotherapy trial

07/06/2018

In the UK, prostate cancer is the most common type of cancer in men. It’s also overtaken breast cancer in recent years to become the third most common type of cancer. That’s why any news when it comes to potential prostate cancer breakthroughs is always exciting. Immunotherapy has been revolutionising the treatment of cancer and now a team from the Institute of Cancer Research and the Royal Marsden Hospital in London have conducted a trial, the results of which they say are "spectacular" and a "big deal". The trial focussed on drugs that boost a patient’s immune system, saving the lives of some men with terminal prostate cancer. Immunotherapy works by helping a person’s immune system recognise and subsequently attack cancer cells. One of the study participants, Michael English, 72, was first diagnosed with prostate cancer in 2005. Radiotherapy, chemotherapy and hormone-based therapies did not kill his cancer, however. Then, two years ago, he started taking the immunotherapy drug pembrolizumab. Today, he is effectively cancer free, with scans no longer showing any signs of the tumour.   However, it’s an approach that will not, unfortunately, help all men. In fact, only between 10% and 15% of patients had any response to the therapy at all. This is not something that’s unusual for immunotherapy. Nell Barrie, from Cancer Research UK, said: "The next step will be to find out how to tell which men will benefit from taking this drug. "This is important as although immunotherapy is exciting, it can have severe side effects".

New prostate cancer test hailed as a breakthrough

24/04/2018

Prostate cancer is the most common cancer in men in the UK, with more than 47,000 new cases diagnosed every year. And up until now, the most widely used tests for the disease had included the PSA blood test, a digital rectal examination (DRE), MRI scans and a biopsy. However, each of these wasn’t without its problems. But now a new ultrasound process, which offers more successful diagnosis and management of prostate cancer, has been identified by researchers at Dundee University. The technique, known as non-invasive shear wave elastography (SWE), offers "much greater accuracy and reliability" than current methods and is less expensive, according to the researchers. It targets the prostate with ultrasound and was evaluated using a study at Dundee University involving around 200 patients. Because cancerous tissue is denser than normal tissue, the shear waves are slowed as they pass through it. During the study, the technique was able to successfully identify 89% of prostate cancers, as well as other more aggressive cancers, including those spreading outside of the prostate. Ghulam Nabi, professor of surgical uro-oncology at Dundee University, said, "Prostate cancer is one of the most difficult to pinpoint. "We are still in a position where our diagnosis of prostate cancer is extremely inefficient, leading to unnecessary treatments for many patients." Speaking about the new test, Prof Nabi said it was “like someone has turned the lights on in a darkened room."

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