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Significant proportion of older adults develop new health conditions after COVID-19

16/02/2022

Initially, when the COVID-19 outbreak first happened, many thought the SARS-CoV-2 virus caused mainly respiratory problems. And while that assumption still holds true, new research shows that the disease can actually impact multiple organs in a person's body.   The new study, the results of which appear in the BMJ, sought to discover whether adults develop other health conditions after a SARS-CoV-2 infection.   For the research, a team led by Dr. Ken Cohen, executive director of translational research at Optum Labs, studied the health insurance records of 133,366 adults aged 65+ in the United States who had received a COVID-19 diagnosis before April 1, 2020.   The researchers compared the records to individuals who did not have COVID-19 in 2019 or 2020 and individuals who had a lower respiratory tract infection but not COVID-19.   The team then identified new conditions occurring 3 weeks or more after each participant’s COVID-19 diagnosis.   Of those individuals who had a SARS-CoV-2 infection in 2020, 32% sought medical attention for a new or persistent condition. This was 11% higher than the comparison group from 2020.   Among the new or persistent conditions were respiratory failure, fatigue, high blood pressure, memory issues, kidney injury, mental health-related diagnoses, hypercoagulability and cardiac rhythm disorders.   Dr. Alicia Arbaje, director of Transitional Care Research at Johns Hopkins Medicine and a clinician at the Johns Hopkins Bayview Medical Center in Baltimore, said: “I think this work is significant. First, because it focuses on older adults, and this is the population that’s most likely to demonstrate long-term effects from this infection, and so I think it’s important and timely given the phase of the pandemic that we’re in.”   [Related reading: Long Covid may hinder women's response, recovery from exercise]   *Image by Michal Jarmoluk from Pixabay

Post-Covid autoimmune response can last months and attack body cells - study

06/01/2022

New research has found that being infected with SARS-CoV-2, the virus that can cause COVID-19, can trigger an immune response which lasts well after the initial infection and recovery, even if the person experiences mild symptoms or is asymptomatic. Infection with a virus causes our bodies to unleash proteins called antibodies which are designed to protect our cells from the foreign invaders (the virus). In some circumstances, however, these antibodies can attack the body's own organs and tissues. According to the research conducted by Cedars-Sinai, people who have had a prior SARS-CoV-2 infection, have a wide variety of autoantibodies up to six months after they have fully recovered, including some which can cause injury to organs and tissues. The study is the first to report not only the presence of elevated autoantibodies after mild or asymptomatic infection but their persistence over time. "These findings help to explain what makes COVID-19 an especially unique disease," said Justyna Fert-Bober, Justyna Fert-Bober, PhD, research scientist in the Department of Cardiology at the Smidt Heart Institute and co-senior author of the study. "These patterns of immune dysregulation could be underlying the different types of persistent symptoms we see in people who go on to develop the condition now referred to as long COVID-19," Fert-Bober added. The research has been published in the Journal of Translational Medicine. *Image by leo2014 from Pixabay 

Long Covid may hinder women's response, recovery from exercise

18/11/2021

While the majority of people who contract COVID-19 recover within 3-4 weeks following infection, there are some who experience lingering symptoms for months afterwards. These symptoms, which can include shortness of breath, loss of smell and taste, brain fog, headaches and fatigue, are referred to collectively as 'long Covid'. Now, research has shown that this so-called long Covid seems to more severely impact women's cardiovascular and lung function than men. According to researchers at Indiana University, Bloomington, women with COVID-19 who had mild-to-moderate illness during the acute phase showed a slower decline in their heart rate after the 6-minute walk test than the participants in the control group. This difference was more pronounced in women actively experiencing long COVID symptoms. Study lead author, Dr. Stephen Carter, a professor at Indiana University, said: “A puzzling feature of post-acute COVID-19 syndrome is the variable presentation of symptoms that appear to be independent of initial illness severity. The present work shows even those with mild-to-moderate initial symptoms can be affected with underlying cardiac-related irregularities with the potential to affect exercise tolerance and/or activities of daily living.” “It’s also plausible that lingering symptoms, particularly muscle/joint pain and/or shortness of breath, may trigger a maladaptive pattern that accelerates systemic deconditioning. However, further research is needed.” The study appears in the journal Experimental Physiology. *Image by StockSnap from Pixabay

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