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Radical Parkinson’s treatment could restore brain cells

28/02/2019

A radical new Parkinson’s treatment that reawakens brain cells damaged by the condition has been tested in people. Patients in the trial were either given the new drug or a placebo. Those who received the drug had it administered via a “port” in the side of their heads which allows it to be delivered directly to their brains. The authors of the study say they saw visual evidence of improvements to the affected areas of the patients’ brains that were given the real drug, glial cell line-derived neurotrophic factor (GDNF), suggesting that it might help regenerate dying brain cells. After an initial safety study, 35 patients took part in the main trial. Half received monthly infusions of GDNF, while the other half received a placebo. Interestingly, both groups of patients showed improved symptoms at the end of the trial, although the group that received GDNF were the only ones who showed actual brain tissue improvements. Speaking about the findings of the trial, Dr Alan Whone, principal investigator, said: “We've shown with the Pet [positron emission tomography] scans that, having arrived, the drug then engages with its target, dopamine nerve endings, and appears to help damaged cells regenerate or have a biological response.” More research is now needed to see if it was actually GDNF that triggered the patients’ improvements and not a so-called placebo effect, where individuals feel better despite them taking medication with no active ingredient.

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