New research suggests that some people have an inherent dislike of certain vegetables. According to the study by Dr Jennifer Smith and colleagues from the University of Kentucky School of Medicine, inheriting two copies of the unpleasant taste gene provides a "ruin-your-day level of bitterness" to foods such as broccoli and sprouts. The research could explain why some people find it really difficult to include certain vegetables in their diets. The team’s findings could also provide some explanation as to why beer, coffee and dark chocolate taste unpleasant to some people. Everyone inherits two copies of a taste gene called TAS2R38, which basically allows us to taste bitterness. However, people can inherit different variants. People who inherit a variant called AVI aren't sensitive at all to bitter tastes. Those who inherit one copy of AVI and another called PAV do experience bitter tastes, but not to extremes. That super-sensitivity for bitter foods is found in people who inherit two copies of the PAV variant - often called "super-tasters". Of the 175 people studied, those with two copies of the bitter taste PAV gene variant ate only small amounts of leafy green vegetables. Speaking to medics at a meeting of the American Heart Association, Dr Smith said: “You have to consider how things taste if you really want your patient to follow nutrition guidelines”.
A compound found only in avocados could help reduce type 2 diabetes, new research suggests. The study by researchers from the University of Guelph in Canada found that a fat molecule called avocatin B, or AvoB - which avocados alone contain – can help strengthen insulin sensitivity and could forestall type 2 diabetes. Initial tests involving mice showed that AvoB slowed weight gain and increased insulin sensitivity by ensuring the complete oxidation of fats. As a result, mice that were given the compound had improved glucose tolerance and utilization. Then, in a separate, double-blind placebo‐controlled human trial, an AvoB supplement was given to people with an average Western diet for 60 days. The researchers found that the participants had tolerated the compound well and no negative effects in the liver, muscles, or kidneys were witnessed. There was also some weight loss among participants that took the supplement, though the authors of the study considered it statistically insignificant. Paul Spagnuolo, Ph.D., an associate professor at the University of Guelph, said the research team will now design clinical trials to assess AvoB's effectiveness in people. Furthermore, they have already received clearance from Health Canada to sell AvoB in powder and pill forms, perhaps as early as next year.
Le diagnostic précoce est l'un des facteurs clés dans la prévention et le diagnostic d'un grand nombre de maladies qui ne présentent pourtant aucun symptôme apparent chez le patient. Les bilans des santé proposés par notre partenaire espagnol, Quironsalud, se focalisent sur une exploration complète, multidisciplinaire et personnalisée, adaptée au sexe, âge et antécédents personnels du patient. A quel moment faut-il faire un check-up ? Des examens médicaux réguliers sont recommandés pour tous ceux qui veulent prendre en main leur santé et pour qui la détection des facteurs de risque dans les meilleurs délais est une priorité. Chez Quironsalud, en une journée, vous pourrez suivre un bilan de santé complet grâce à une coordination et un parcours de soins conçu spécifiquement à cet effet, pour le confort du patient et de son entourage. Les bilans de santé proposés par Quironsalud s’adressent à chacun d’entre nous. Que vous soyez en bonne santé, que vous souffriez d’une maladie chronique ou que vous présentiez certains symptômes bien spécifiques, les équipes médicales des établissements de santé QuironSalud sauront vous proposer le bilan personnalisé adapté à vos besoins. Dans cas, comme par exemple pour des patients souffrant de cancer ou de maladies cardiovasculaires, un contrôle périodique peut vous être proposé pour vous permettre de suivre au plus près l'évolution ou la rémission de votre pathologie. Si vous adoptez le programme patient international proposé par le groupe QuironSalud, tout sera mis en œuvre pour faciliter l’organisation de vos consultations, y compris, l’aide à la planification du voyage, facilitation pour l’obtention du visa, prise en charge à l'aéroport/gare et le transfert à la clinique ou à votre hôtel. Un service de traduction est à aussi à votre disposition ainsi qu'un accompagnateur qui sera à votre écoute tout au long de votre séjour au centre médical Quironsalud. Pour plus d'informations, contactez-nous dès maintenant au : email@example.com ou par téléphone au +33 953 02 03 09.
An innovative new blood test can detect breast cancer up to 5 years before symptoms appear, researchers say. Developed by a team at the University of Nottingham, England, the new blood test identifies specific immune system ‘autoantibodies’, which are produced when tumor-associated antigens (TAAs) are present – like those produced by breast cancer cells. While the test is still only partially effective, it could eventually provide the best chance of detecting breast cancer early, enabling faster treatment and a greater chance of success. In the pilot study, the researchers took blood samples from 90 breast cancer patients when they were diagnosed with breast cancer. They then matched these samples with ones from 90 patients without breast cancer. Then, they used a technology called protein microarray to test the blood samples for the presence of autoantibodies and 40 TAAs associated with breast cancer, plus another 27 TAAs that were not known to be linked with the disease). The researchers used a technology called protein microarray to rapidly test the blood samples for autoantibodies against 40 TAAs associated with breast cancer, plus another 27 TAAs that were not known to be linked with the disease. Speaking last Sunday at the U.K. National Cancer Research Institute conference in Glasgow, Scotland, researcher Daniyah Alfattani, a Ph.D. student at the University of Nottingham's Centre of Excellence for Autoimmunity in Cancer (CEAC), said: “The results of our study showed that breast cancer does induce autoantibodies against panels of specific tumor-associated antigens. We were able to detect cancer with reasonable accuracy by identifying these autoantibodies in the blood.” At present, annual mammograms are the best way for doctors to detect the presence of breast cancer while in its early stages.
Type 2 diabetes is a chronic condition that occurs when a person’s body ineffectively uses insulin. It is the most common form of diabetes, accounting for 90% to 95% of the more than 30 million diabetes cases in America today. Despite rising numbers, it is estimated that around 80% of new type 2 diabetes diagnoses could be prevented with lifestyle changes and more education. But while it’s been known for some time that when added to a genetic predisposition, factors like being overweight and a lack of physical activity increase a person’s risk of developing type 2 diabetes, very little research has been done to determine the impact of other environmental factors. That’s why a new study by a team from the University of Illinois at Chicago (UIC) School of Public Health which set out to determine if type 2 diabetes risk changes between urban and rural environments is interesting. According to the research - which involved examining 3,134 people across the United States - the quality of the air, water, and land, as well as numerous sociodemographic factors, such as education, average household income, violent crime rates, or property crime rates has an impact on a person’s type 2 diabetes risk. So-called ‘built domain factors’ were also used. These included how many fast-food restaurants were in a particular area; how many fatal accidents occurred, and how many highways, roadways, or public housing units there were. The research found that a poorer environmental quality was linked with a higher prevalence of type 2 diabetes. Specifically, inferior air quality and built and sociodemographic factors were associated with a higher risk of diabetes in rural areas, while in urban areas, only air and sociodemographic factors were associated with diabetes risk. “There might be something happening in rural areas that is different than in urban areas. Our findings suggest that environmental exposures may be a bigger factor in rural counties than in urban areas in the U.S.,” explains Dr. Jyotsna Jagai, lead author.
Obesity is worryingly common across the world today. World Health Organization statistics from 2018 show that global obesity has almost tripled since 1975 and most of the world’s population now live in a country where being overweight or obese kills more people than being underweight. But while obesity is known to increase a person’s risk of certain health conditions, new research has revealed that it does not seemingly affect men and women in the same way. According to the study from Oxford University in the United Kingdom, the findings of which are summarized in the journal PLOS Genetics, the risks of developing different health problems as a result of being obese are different for men and women. For example, obese women are at higher risk of developing type-2 diabetes than men. Meanwhile, obese men have a higher risk of chronic kidney disease and chronic obstructive pulmonary disease. The team says their findings add to the existing evidence that preventing and treating obesity is a crucial step in countering the emergence of other health conditions. “This study shows just how harmful carrying excess weight can be to human health, and that women and men may experience different diseases as a result,” said first author Dr. Jenny Censin. For the study, the team from Oxford University analyzed genetic information and three different obesity measures in a cohort of 195,041 men and 228,466 women.
In vitro fertilization (IVF) is one of several techniques that can be used to help people with fertility problems have a baby. With IVF, an egg is removed from the woman’s body and fertilized with sperm in a laboratory. The fertilized egg – known as an embryo – is then placed inside the woman’s womb where it will hopefully implant in the lining of her uterus and grow and develop. IVF can be carried out using a woman’s eggs and her partner’s sperm, or eggs and sperm from donors. There are seven main stages associated with IVF treatment: Ovary stimulation – Medication is used to encourage the woman’s ovaries to produce more eggs than usual. Progress monitoring and maturing of eggs – Ultrasounds and blood tests are used to monitor the eggs, while medication is administered to help them develop. Egg retrieval – A needle is used to collect eggs from each ovary. This step takes around 30 minutes and the woman can usually go home afterwards. Egg fertilization – The retrieved eggs are mixed with sperm. They have the chance to find each other and fertilize the same as they would inside the body. Embryo development – If the sperm fertilizes the egg, it becomes an embryo. The embryo is then placed inside a special incubator where conditions are perfect to encourage growth and development. Embryo transplant – Once the IVF specialists are satisfied that the embryo is developing correctly, it is then transplanted into the woman’s uterus. Final blood test – Approximately two weeks after the embryo has been transplanted, a final blood test is performed to check the woman’s hCG (human chorionic gonadotropin) levels, which are used to determine if she is pregnant or not. It is important to note that not all eggs, unfortunately, will fertilize and reach the embryo stage. This can occur as a result of immature eggs and/or weak sperm. If you and your partner have been struggling to conceive naturally, IVF could help you get pregnant. Find out more about how we can facilitate IVF treatment for French-speaking patients in Spain by contacting us today.
People who take daily blood pressure medication should take it just before bedtime to get the most out of it, researchers say. Writing in the European Heart Journal, the researchers say that while it may sound like a very simple tip, it’s one that could save lives. The reason why taking such medication at bedtime is more beneficial is because our body clocks alter the way our bodies respond to it. At night, our blood pressure is typically lower than it is during the day. However, if for some reason our blood pressure does not dip and remains consistently high, our chances of having a stroke or heart attack significantly increase. The study found that patients who took their daily blood pressure medication before bedtime had significantly lower average blood pressure both at night and during the day than those who took their medication in the morning. Their blood pressure also dipped more at night. Lead researcher Prof Ramon Hermida, from the University of Vigo in Spain, said doctors should consider recommending their patients take their daily blood pressure medication at night going forward – especially as it’s “totally cost-free. It might save a lot of lives. “Current guidelines on the treatment of hypertension do not recommend any preferred treatment time. Morning ingestion has been the most common recommendation by physicians based on the misleading goal of reducing morning blood pressure levels. “The results of this study show that patients who routinely take their anti-hypertensive medication at bedtime, as opposed to when they wake up, have better-controlled blood pressure and, most importantly, a significantly decreased risk of death or illness from heart and blood vessel problems.” The next step is to determine whether the findings of the study apply to different brands of blood pressure medication. Lifestyle factors that have an impact on blood pressure: Smoking Drinking too much alcohol Being overweight Not doing enough exercise Eating too much salt
Researchers have found fat in overweight and obese people’s lungs. It’s the first time such a discovery has been made and could provide important clues as to why overweight and obese people have an increased risk of asthma. For the research, a team from Australia analysed lung samples from 52 deceased individuals. They found the amount of fat present increased in line with Body Mass Index (BMI). Being overweight/obese is already linked to having asthma, but it was previously thought that excess weight pressing on the lungs was the main reason for this. However, the Australian researchers say fatty tissue in the walls of airways takes up space and causes inflammation, which can lead to wheezing and asthma. Speaking about the findings of the research, which are published in the European Respiratory Journal, Dr Peter Noble from the University of Western Australia said: “We’ve found that excess fat accumulates in the airway walls where it takes up space and seems to increase inflammation within the lungs. “We think this is causing a thickening of the airways that limits the flow of air in and out of the lungs, and that could at least partly explain an increase in asthma symptoms.” Experts say that more research is now needed to find out whether the build-up of fatty tissue could be reversed through weight loss. In the meantime, asthma patients should be supported to achieve a healthy weight.
Tiny microphones could provide invaluable insights into a person’s knee health, a new study suggests. According to researchers, arthritic knees are ‘noisy’ and emit telltale sounds - but sounds that can only be heard by microphones. The waveforms emitted by the noisy knees can then be analysed by computers to provide insights into the health of the knee. The researchers say the technology – similar to the kind used by engineers to listen for faults in bridges - can be used to better diagnose conditions like osteoarthritis and help develop better treatments as a result. For the study - conducted by a team from Lancaster University, the University of Central Lancashire and Manchester University – patients with osteoarthritis were asked to stand up and down five times, while acoustic signals from their knees were captured by the microphones. The theory behind the trial is that knees which are functioning normally should act like smooth and well-lubricated engineering structures, emitting very little in the way of noise. In comparison, rough and poorly-lubricated surfaces (arthritic knees) would generate acoustic signals. The trial found that the microphone technique could distinguish between the two different types of knee, thus offering a solution that did not involve an X-ray. Publishing its findings in the journal PLOS ONE, the research team said the more noisy the knee, the more severe the osteoarthritis. However, they did admit that more research and larger-scale trials are needed so the technique can be developed further.
A cost effective and widely available drug could help save hundreds of thousands of lives each year if it was given to patients brought into hospitals with head injuries, a new study has found. The drug, tranexamic acid, helps stop bleeding in and around the brain, arresting damage that can occur post-trauma. It’s already approved for clinical use and is routinely taken to prevent internal bleeding in other parts of the body following trauma, as well as women with dangerous bleeding after childbirth. According to the study published in The Lancet, if given early enough, tranexamic acid can improve patient survival rates. While it cannot reverse trauma damage, it can prevent a small bleed becoming worse. The team from the London School of Hygiene and Tropical Medicine (LSHTM) tested tranexamic acid on almost 13,000 patients. They found that if given within three hours of a head trauma, the number of fatalities was reduced by as much as 20%. Furthermore, tranexamic acid is a cost effective treatment, with a course in the UK costing around £6.20 (7.09 euros) per patient. Speaking about the findings of the trial, one of the lead investigators, Prof Haleema Shakur, from the LSHTM, said: “The results are just amazing. It's the first trial to ever show that a [medical] treatment can reduce the risk of traumatic brain injury patients dying. “This is the first time that we have seen a beneficial effect. It will have huge implications worldwide. “It's a widely available drug, it's relatively cheap and it's really simple to give.”
Lycopene - a natural pigment that gives red fruits and vegetables their colour - is an antioxidant that protects against cell damage, and tomatoes contain plenty of it. In fact, it is estimated that tomatoes account for 80% of the lycopene in the US diet. Now, a new study suggests Lycopene may also help boost sperm quality. According to the research by a team at the University of Sheffield, healthy men who consumed the equivalent of two tablespoons of concentrated tomato puree each day were found to have better quality sperm. During the 12-week trial, 60 men were randomly selected to take 14mg of lactolycopene supplement each day. The reason a supplement was used is because the participants would have had to eat 2kg of tomatoes each day to obtain an equivalent dose of lycopene. The participants’ sperm was tested before, during and after the trial. While there was no difference in sperm concentration, the men who had been taking the lycopene had healthier and faster sperm. Encouraged by the results, the researchers now want to expand the trial to include more men and see if the findings are the same. Lycopene has also been previously linked to other health benefits, including a lowered risk of heart disease and certain cancers.
Male breast cancer is pretty rare. In fact, it accounts for just 1% of all breast cancer cases. That’s why very few studies have looked at what factors can lead to more positive outcomes for patients. To address this reality, researchers from Mayo Clinic in Rochester, Minnesota, have conducted one of the largest male breast cancer studies to date, the findings of which are published in the journal Cancer. The researchers found that 51% of male breast cancer diagnoses occurred between the ages of 50 and 69, and that the average age of diagnosis was 64. In fact, only 15% of the patients were diagnosed before the age of 50. Interestingly, the study authors found that black men, older patients, individuals with other ongoing health issue and those with higher tumor grade and stage had poorer prognoses. Furthermore, they found that patients who underwent a full mastectomy also had poorer outcomes. The prognosis was better for patients who lived in wealthier areas, whose tumors carried the progesterone receptor and men who received radiation therapy, chemotherapy or anti-estrogen therapy. While female breast cancer treatment has improved dramatically over the years, the study authors say it is unclear whether these advancements have been applied to the management of male breast cancer too. Two of the reasons for this are because male breast cancer usually occurs later in life and it commonly spreads to the person’s lymph nodes. The researchers hope their paper will shine some more light on this little known condition and lead to better outcomes for patients going forward.
A new study has found that if people with type-2 diabetes achieve just 10% weight loss within 5 years of being diagnosed, they are twice as likely to experience remission at the 5-year follow-up as those who haven’t lost any weight. The findings of the study by researchers from Cambridge appear in the journal Diabetic Medicine and were obtained through analysis of 867 people aged 40-69 with newly diagnosed type-2 diabetes. Having followed the study participants for 5 years, the researchers found that 257 (30%) had diabetes in remission. Speaking about their findings, first author Hajira Dambha-Miller, Ph.D. said: “Our results suggest that it may be possible to get rid of diabetes, for at least 5 years, with a more modest weight loss of 10%. This will be more motivating and hence more achievable for many people.” The fact diabetes can be sent into remission with just moderate weight loss – and not just the drastic intensive weight loss measures we’ve known about for some time - will be welcome news for many people living with the condition. It reinforces the importance of managing one’s weight through dietary choices and physical exercise. Going forward, the Cambridge team hopes to be able to use the research to help medical professionals better support patients with type-2 diabetes and reduce their symptoms.
Some species of bacteria are stripping off their outer layers in an attempt to evade antibiotics and survive. It’s a reality that could explain why some infections keep coming back. According to researchers at Newcastle University in the UK, the bacteria are “undressing” and removing their cell walls – the very part of them that some antibiotics target. The cell walls of some bacteria are made from sugars and amino acids. While they give the bacteria shape and protection, these walls provide a weak spot that can be exploited by antibiotics. Penicillin, the first antibiotic to be discovered and the most widely used in the world, works by disrupting the cell wall and causing the bacteria to burst. The study, which is published in the journal Nature Communications, found that bacteria associated with recurring urinary tract infections in elderly patients slipped out of their cell walls to avoid the effect of the antibiotics. It’s the first time that research has shown bacteria using this method to survive antibiotic treatment and while not all survive – most get taken care of by the body’s immune system - it does offer some explanation as to why certain infections come back again and again. The discovery could pave the way for new treatments to be developed, including combination therapies that target both the bacteria’s cell wall and inner workings.
Gum disease is linked to an increased risk of hypertension, a new study has found. Furthermore, the more sever the gum disease, the greater a person’s risk of high blood pressure. The research by University College London's Eastman Dental Institute – the findings of which appear in the journal Cardiovascular Research – shows people with periodontitis (an advanced form of gum disease) have a higher risk of hypertension. Hypertension, according to the Centers for Disease Control and Prevention (CDC), affects 32% of all American adults, and as many as 47.2% of people aged over 30 have some form of gum disease, which is why the new research is so intriguing. While the two conditions may appear to be completely unrelated, the new research shows otherwise. And when you consider that high blood pressure is the leading cause of premature death worldwide, affecting up to 45% of adults, the findings of the study could result in much more attention being paid to combatting gum disease going forward. Specifically, the research revealed an association between moderate-to-severe periodontitis and a 22% higher risk of hypertension, Moreover, severe periodontitis was linked to a 49% higher risk of hypertension. Speaking about the findings of their research, senior author Prof. Francesco D'Aiuto, from the University College London Eastman Dental Institute in the United Kingdom, said: “Previous research suggests a connection between periodontitis and hypertension and that dental treatment might improve blood pressure, but to date, the findings are inconclusive. “Hypertension could be the driver of heart attack and stroke in patients with periodontitis,” he added.
A new tumour-agnostic drug has been approved for use in Europe. The revolutionary drug, experts say, has the potential to cure more cancer patients and reduce side-effects. Called larotrectinib, the new drug does not care where the cancer is growing in the body and instead looks for a specific genetic abnormality, which means it can be used to treat a wide range of tumours. Doctors in the UK have said the new drug is “a really exciting thing” and marks a move away from having ‘drugs that treat breast cancer’, ‘drugs that treat bowel cancer’ and ‘drugs that treat lung cancer’, to having drugs that target the genetic make-up of each patient’s tumour. However, the decision by European regulators does not mean that any cancer patient can take advantage of larotrectinib right away. Its approval for use right now only applies to patients with solid tumours that have been caused by a genetic abnormality known as an NTRK gene fusion. This rare abnormality happens when part of an individual’s DNA accidentally merges with another, leading to an alteration in the body’s blueprint that allows cancer to grow. Speaking about the drug development, Dr Julia Chisholm, a children's cancer consultant at the Royal Marsden Hospital in London, said: “It is a really exciting thing, as is it works across a range of cancers. It's not confined to one.”
The method via which a baby is born has a dramatic impact on its gut bacteria and could explain why babies born by Caesarean section are more likely to experience health problems later in life, a new study has found. The study by Wellcome Sanger Institute, UCL, and the University of Birmingham – the largest of its kind – looked at babies’ microbiomes (the bacteria, viruses and fungi that live in our guts) to see if they formed differently depending on how a baby was born. For the research, samples were taken on a regular basis from the nappies of 600 babies in their first month of life. The results showed that vaginally born babies got most of their first bacteria from their mothers. However, babies born via Caesarean section showed high levels of hospital bugs, with some having as much as 30% of their total microbiomes made up by such bugs. It’s a reality that could explain why babies born by Caesarean section are more susceptible to certain conditions when they are older, like allergies, asthma and type 1 diabetes. Speaking about the findings of the research, Dr Trevor Lawley, from the Wellcome Sanger Institute, said: “What surprised me and scared me was the amount of healthcare bugs showing up in these children. “But what excites me is we have an amazing body of data now that we can build on, to think about how to properly establish the human ecosystem, starting at birth.”
A team of international scientists has discovered that a drug usually used to treat enlarged prostates may be beneficial in the fight against Parkinson’s disease. The drug, Terazosin, helps ease the discomfort associated with an enlarged prostate (benign prostatic hyperplasia, or BPH) by relaxing muscles in the prostate and part of the bladder. This helps relieve symptoms like difficulty in beginning to urinate and needing to urinate frequently or urgently. Now, researchers believe it may also help slow the progression of Parkinson’s by protecting brain cells from being damaged – something that is not possible at present. For the research, the team of scientists studied thousands of patients with both BPH and Parkinson's disease. They found that Terazosin boosted energy production in brain cells and slow neurodegeneration. It does this by activating an enzyme called PGK1. Publishing their findings online in the Journal of Clinical Investigation, the scientists said that while it was too premature to talk about a cure for Parkinson’s, their research was ‘exciting’ and could have the potential to change the lives of people with Parkinson’s disease going forward. Because Terazosin is already approved for use in patients with enlarged prostates, getting it repurposed as a Parkinson’s drug also shouldn’t be a problem.
A new way of cooling human livers could significantly extend the time they can be kept ahead of an organ transplant By supercooling livers to -4C, researchers have been able to triple their viable lifespan to more than one day. It could revolutionise the way organs are stored in the future and allow even more people to benefit from transplants. The team from Massachusetts General Hospital and Harvard Medical School pioneered the technology using rats’ livers five years ago. The tiny livers were supercooled, while nutrients and oxygen were pumped around their blood vessels. But developing the technique to work with human organs wasn’t without its challenges. Because they are much larger, human livers are at greater risk of ice crystals forming, which can rupture cells and kill tissue. To overcome this, the researchers used protective agents to prevent the livers from freezing. As a result, they were able to extend their viable lifespans to 27 hours – a significant increase on the current nine hours when organs are stored on ice. Once brought back up to temperature, the livers were found to function normally and also responded as expected when connected to an artificial blood supply. One of the researchers, Dr Reinier de Vries, said: “This is a big breakthrough in organ preservation. “This is the first time that we actually show that it is feasible to preserve human organs at sub-zero temperatures.”
Simple educational and motivational text messages can help people with diabetes manage their blood sugar better, a new study has found. It is not only an extremely affordable and scalable measure, but one that can be applied globally. According to the six-month Chinese study, diabetes patients who received the text messages and standard care reduced their glycated hemoglobin (HbA1c ) by more than patients who just received standard care. The results showed an average reduction in HbA1c of 2 mmol/mol (0.2%) in patients who received the supportive text messages. The group that did not receive the text messages experienced an average increase in HbA1c of 1 moll/mol (0.1%). For the study, the participants were split into two groups: one that received standard diabetes care and two text messages each month thanking them for their participation, and another group that received standard care and up to six text messages per week containing information on subjects like dietary advice, physical activity, emotional support and blood glucose monitoring. As well as actually reducing their HbA1c, the group receiving the supportive text messages also had a greater proportion of patients who achieved their HbA1C target of less than 7% (69.3% vs. 52.6% in the control group). Speaking about the findings of the study, Dr Xiqian Huo, of Beijing's Fuwai Hospital, said: “Lifestyle advice such as strict dietary control may have contributed to glycemic improvements, together with reminders to monitor blood glucose regularly. The messages were designed to provide information and motivation, and help patients set goals and manage stress.” The results of the study were presented at the annual meeting of the European Society of Cardiology on Saturday, August 31 also appear in journal Circulation: Cardiovascular Quality and Outcomes.
Cancer has surpassed cardiovascular disease as the biggest killer of middle-aged people in higher-income nations, a study suggests. Globally, stroke and heart problems are the leading causes of death among this age group. But the findings of this latest research led by a team from Canada's McMaster University shows that middle-aged people in rich nations are 2.5 times more likely to die of cancer than cardiovascular disease. In contrast, people in poor countries are three times more likely to die from cardiovascular disease. The study, published in The Lancet, is drawn from a global research program, the Prospective Urban and Rural Epidemiologic (PURE) study, involving 160,000 people from 21 different countries. While cardiovascular disease accounted for more than 40% of deaths in middle- and low-income countries, it only accounted for less than a quarter in richer nations. The researchers say this could be due to people living in richer countries receiving more medication and support. Speaking about the findings of the research, Gilles Dagenais, a professor at Quebec’s Laval University in Canada who co-led the work, said: “Our report found cancer to be the second most common cause of death globally in 2017, accounting for 26% of all deaths. But as (heart disease) rates continue to fall, cancer could likely become the leading cause of death worldwide, within just a few decades.”
Drinking red wine (in moderation) could be good for your gut, according to researchers from the UK. The team from King’s College London says red wine contains compounds that help increase the number of different types of bacteria that live in the gut. The micronutrients, known as polyphenols, are more abundant in red wine vs. beer, cider and white wine, and act as fuel for microbes living inside the bowel. Polyphenols are found in many fruits and vegetables, including the grapes used to make red wine. The researchers say even just one glass of red wine a fortnight can make a difference, but warn that their findings should not be used as an excuse to binge drink. Publishing its research in the journal Gastroenterology, the team said the “friendly” bugs in our gut help keep us healthy. Even small changes in our gut microbiota – the community of bugs that live there – can make us more susceptible to conditions like obesity, heart disease and Irritable Bowel Syndrome. The gut microbiota of people who drink red wine was found to be more diverse than that of those who do not drink wine. Furthermore, the more wed wine consumed, the greater the levels of diversity – although it’s important to note that nobody involved in the trial was a heavy drinker. Speaking about the findings of their research, Dr Caroline Le Roy said: “If you must choose one alcoholic drink today, red wine is the one to pick as it seems to potentially exert a beneficial effect on you and your gut microbes, which in turn may also help weight and risk of heart disease.”
A pill that contains four different medicines and is designed to be taken daily could dramatically reduce the number of heart attacks and strokes, a new study has found. The polypill – which is the generic term used to describe a medication that contains multiple active pharmaceutical ingredients – contains aspirin, a cholesterol-lowering statin and two drugs to reduce blood pressure. For the study, researchers from Iran and the UK studied around 6,800 people from more than 100 villages in Iran. Half were given the polypill and advice on how to improve their health through lifestyle changes and the other half were just given the lifestyle changes advice. After five years, the group taking the polypill had experienced 202 cardiovascular events, while the group that had just been given the advice had experienced 301 cardiovascular events. In other words, the group taking the polypill had experienced around a third less cardiovascular events. The researchers say the pill costs just pennies a day, but could have a huge impact, especially in poorer countries where doctors have fewer options available to them. Stroke and coronary heart disease are the top two causes of death worldwide, killing more than 15 million people each year. Obesity, smoking and doing little exercise are all risk factors associated with an unhealthy heart. Based on the findings of the study, if 35 people were all given the polypill daily, it would prevent one of them developing a major heart problem within 5 years. “Given the polypill's affordability, there is considerable potential to improve cardiovascular health and to prevent the world's leading cause of death,” said Dr Nizal Sarrafzadegan, of Isfahan University of Medical Sciences, Iran. The findings of the research are published in The Lancet.
Having high blood pressure before middle age may pose a risk to brain health in later life. According to a new study, the results of which are published in The Lancet Neurology, the “window of opportunity” to safeguard brain health runs from the mid-30s to the early-50s. And having high blood pressure in the 30s and 40s could lead to blood vessel damage and brain shrinkage. For the study, a team of researchers from UCL Queen Square Institute of Neurology followed 500 people born in 1946. Throughout the study, participants had their blood pressure measured and had brain scans. The researchers found that blood pressure increases between the ages of 36 and 43 were linked to brain shrinkage. Moreover, blood pressure increases between 43 and 53 were associated with blood vessel damage or “mini strokes” when people reach their 70s. Speaking about the findings of the research, Dr Carol Routledge, director of research at Alzheimer's Research UK, said: “High blood pressure in midlife is one of the strongest lifestyle risk factors for dementia, and one that is in our control to easily monitor and manage. “Research is already suggesting that more aggressive treatment of high blood pressure in recent years could be improving the brain health of today's older generations. “We must continue to build on this insight by detecting and managing high blood pressure even for those in early midlife.”
People with type-2 diabetes get no benefit from taking omega-3 fish oil supplements, a new study has found. According to researchers from the University of East Anglia, while omega-3 supplements are not harmful for people with type-2 diabetes (this has been a concern previously), they don’t provide any benefit either. This contradicts a common belief that omega-3 can protect against diabetes and even reverse the condition. The study, which involved 58,000 participants, found that people who consumed more omega-3 had the same risk of developing diabetes as individuals who did not. Furthermore, taking omega-3 fish oil did not influence levels of blood glucose, insulin and glycated haemoglobin - all measures of how the body handles sugar. ‘Better to eat fish’ Douglas Twenefour, deputy head of care at Diabetes UK, said: “Eating a healthy, varied diet is incredibly important, and we know that certain foods - including fruits, vegetables, wholegrains, yoghurt and cheese - can help to lower your risk of type 2 diabetes. “While omega-3 fatty acids are crucial for our overall health, it's generally better for people with type 2 diabetes to get their intake by eating at least two portions of oily fish a week, than by taking supplements." The advice from Dr Lee Hooper, who led the research, is to forego the expensive omega-3 supplements and instead buy oily fish and/or spend your money on physical activity, which will have more of a positive impact when it comes to type-2 diabetes.
It’s widely accepted that eating more fruits and vegetables is beneficial to a person’s health. But now a new study has firmly and scientifically concluded that eating foods that are rich in flavonoids (like fruits and vegetables) could stave off disease and extend life. According to research by a group of scientists from Edith Cowan University, Australia, people who eat 500mg of flavonoids every day have the lowest risk of cancer and cardiovascular disease-related deaths. So how much do you need to eat to reap these benefits? Well, the scientists say it is important to get the flavonoids from a variety of sources. They say someone can achieve the 500mg of total flavonoids by consuming one cup of tea, one apple, one orange, 100g of blueberries and 100g of broccoli. Interestingly, the study of more than 50,000 adults found that the benefits of consuming 500mg of flavonoids daily were most pronounced in people who smoke and drink more than two alcoholic beverages every day. However, the scientists were quick to point out that consuming flavonoids does not enough to undo the harmful effects of smoking and high alcohol consumption. The study also found that consuming more than 500mg of flavonoids daily was not associated with any additional benefits. The paper appears in the journal Natural Communications.
Osteoporosis is a disease that causes bone quality and density to decline over time. As a result, people with osteoporosis are at greater risk of fracturing bones. And it’s often not until a fracture occurs that an individual realises they have osteoporosis. That’s because the disease affects bones silently and progressively, with few symptoms. Following a fracture, osteoporosis patients are often prescribed medication to help support their bone health. Common osteoporosis drugs include etidronate and nitrogen bisphosphonates (usually alendronate and risedronate). Now, new research has revealed just how effective these drugs are. According to two different studies conducted by the Garvan Institute of Medical Research in Darlinghurst, Australia, osteoporosis drugs not only reduce the risk of further fractures, but also decrease a person’s risk of premature death. In the first study, the research team analysed data relating to over 6,000 osteoporosis patients aged 50 and over. They found that people taking alendronate had a 34% lower risk of premature death. For the second study, the researchers looked specifically at how nitrogen bisphosphonates impact bone loss and mortality risk in women aged 50 and over. They found that patients who took nitrogen bisphosphonates had both a lower rate of bone loss and a lower mortality risk. However, the studies also revealed that many osteoporosis patients do not follow their drug prescriptions and neglect to take the necessary drugs. Speaking about the findings of the two trials, lead author Dana Bliuc, Ph.D. said: “For many individuals with osteoporosis, bone health isn't front-of-mind. We hope our study results will encourage people with osteoporosis or at risk of a fracture to seek treatment — and commit to taking it.” So the advice is clear: if you have been prescribed osteoporosis drugs, make sure you take them as directed.
While exercise has long been thought to help boost mental health and there’s evidence to support this, less is known about whether physical activity can actually prevent the onset of mental health conditions such as anxiety and depression. Indeed, previous studies have suggested that low levels of physical activity are associated with a greater incidence of several common mental health problems, but few studies have investigated whether the opposite is true: more exercise = less risk of developing mental health disorders – until now. By conducting a systematic review and meta-analysis of four different studies, the researchers from University College London were able to assess the impact of physical exercise on mental health risk. Publishing their findings in the Journal of Affective Disorders, the researchers said low and medium levels of cardiorespiratory fitness are associated with a 47% and 23% greater risk of common mental health disorders, compared with high levels of cardiorespiratory fitness. In other words, doing more physical exercise does seem to have a positive impact on a person's mental health risk. The research makes for interesting reading when you consider that mental health issues are growing and not everyone benefits from therapies and medication. The researchers are now planning to explore this avenue further to see if they can identify the underlying mechanisms of the relationship between exercise and mental health.
Eating chocolate makes us feel good, right? But is there actually any evidence that it can combat conditions like depression? Well, a new survey-based study of over 13,000 people suggests there is, but only if you eat dark chocolate. Having analysed data from the United States National Health and Nutrition Examination Survey, the researchers concluded that there was no link between eating dark chocolate and a reduction in depressive symptoms. However, when they looked specifically at dark chocolate consumption, they found people who ate this type of chocolate were 70% less likely to report depressive symptoms than individuals who ate no chocolate at all. Furthermore, the analysis also showed that people who ate the most chocolate (regardless of type) were less likely to experience depression than people who ate no chocolate. While chocolate lovers might rejoice at these findings, more research is needed. That’s because the study is merely observational, so no causational conclusions can be drawn. If subsequent research is performed and does suggest that a link exists between eating chocolate and a lower risk of depression, the biological reasons why will need to be investigated. For now, if you’re a fan of dark chocolate in moderation, you could be reducing your chances of developing depression.
A new mobile phone app that helps speed up the detection of a potentially fatal kidney condition has been described as a “potential lifesaver” by hospital staff. The app, known as Streams, is able to detect acute kidney injury in 14 minutes (on average). Until now, this process would have taken at least several hours. This is highly significant as acute kidney injury can begin to affect other organs if it is not treated quickly. One in five people who are admitted to hospital develop acute kidney injury and it leads to around 100,000 deaths in the UK each year. The app works by looking for a waste product called creatinine, something that is normally filtered out by a person’s kidneys. It then sends warning signals to front-line clinicians’ phones if a patient’s blood tests indicate they have acute kidney failure. Streams was developed by the Royal Free Hospital in London and technology firm DeepMind, which is owned by Alphabet. Speaking to the BBC, Mary Emerson, lead nurse specialist at the Royal Free Hospital, said: “It's a huge change to be able to receive alerts about patients anywhere in the hospital. Healthcare is mobile and real time, and this is the first device that has enabled me to see results in a mobile real-time way.” The findings of the app trial are published in the journal Nature Digital Medicine.
New research suggests that tickling the ear with a small electric current could help rebalance the body’s nervous system in people over-55 and help them age more healthily. The therapy works by stimulating the vagus nerve, the longest of the nerves that connect the brain with other parts of the body such as the heart, lungs and gut. The vagus nerve is usually difficult to access and usually requires surgical intervention so that electric stimuli can be delivered. However, one small branch of the vagus nerve reaches a part of the outer ear and that’s where the researchers from the Universities of Leeds and Glasgow — both in the United Kingdom – stimulated it from. Patients who received the electric stimuli for 15 minutes a day over a 14-day period noted improvements in body, sleep and mood. As we age, our body’s nervous system gradually becomes out of balance and the sympathetic branch begins to dominate. This makes us more prone to diseases, such as hypertension and heart problems, as well as anxiety and depression. The researchers found that the electric ear tickling therapy – named so because that’s how it feels – helped rebalance the body’s nervous system by increasing parasympathetic activity and decreasing sympathetic activity. People with the greatest imbalance at the start of the trial showed the biggest improvement at the end.
By adding just a handful of nuts to their daily diet, men could improve their sexual function, a study suggests. The 14-week trial, which involved 83 men split into two groups, found that adding 60 grams of almonds, hazelnuts and walnuts to a Western-style diet benefitted sexual function. Reporting their findings in the journal Nutrients, the authors of the study said the group of men who ate the extra nuts each day showed significant increases in two measures of erectile and sexual function: orgasmic function and sexual desire. A previous analysis of the trial data in 2018 yielded signs that eating more nuts also improves sperm quality. “Including nuts in a regular diet significantly improved auto-reported orgasmic function and sexual desire,” the Spanish researchers concluded. They are now calling for further, large-scale studies to determine the effect of eating nuts on sexual function – especially as separate research found that consuming pistachios helped improve erectile function. The theory is that pistachios, like many other nuts, contain antioxidants and arginine, a powerful compound that increases vasodilatation. So, if you are not easily able to follow a Mediterranean diet, rich in fruit, vegetables and nuts, you could still reap some of the sexual function rewards by adding just a handful of nuts to your daily diet.
If you’re looking to lose some weight, eating earlier in the day and intermittently fasting could help, new research suggests. According to a paper published in the journal Obesity, the timing of meals and intermittent fasting influences metabolism, which can have an impact on weight loss. Researchers discovered this following a trial involving 11 men and women, all of who were in good health, aged between 25 and 45 years and carrying some excess weight. The trial participants were split into two groups: one who ate breakfast at 08:00 and then ate their last meal of the day at 14:00, and another who ate breakfast at 08:00 and had their last meal of the day at 20:00. Both groups ate the same meals each day. At the end of the trial, participants underwent a battery of tests in a respiratory chamber to assess their metabolism. The number of calories, fat, carbohydrates and proteins burned were all measured. It was revealed that the participants who ate their last meal of the day at 14:00 and, therefore, fasted longer overnight, burned more fat than the other group. They also had lower levels of the hunger hormone ghrelin. “Eating in sync with circadian rhythms by eating early in the daytime appears to reduce body weight and improve metabolic health,” the authors of the paper wrote.
Most people feel nervous ahead of surgery, even if the procedure they’re about to undergo is straightforward. To calm these nerves, patients are often given medication. But a new study suggests that music could be just as effective. According to a study conducted by researchers at the University of Pennsylvania, a special song written to reduce anxiety, blood pressure and heart rate performed as well as a sedative for calming patients ahead of surgery. For the trial, 157 surgery patients were either given the drug midazolam or play the so-called “world’s most relaxing song”, Weightless by UK band Marconi Union, while they were being given an anaesthetic to numb a part of their body. Patient anxiety was equally reduced in both groups, suggesting the music was an effective alternative to the drugs. The great news about this is the music medicine is both free and completely safe, whereas the drugs cost money and can have side effects. Speaking about the findings of the research, Dr Veena Graff, assistant professor of anaesthesiology and critical care at the University Of Pennsylvania Perelman School Of Medicine, said: “Music lights up the emotional area of the brain, the reward system and the pleasure pathways. “It means patients can be in their own world, they can be comfortable and have full control.” Intrigued what the world’s most relaxing song sounds like? Listen to it here: https://www.youtube.com/watch?v=2JNM-xPZXgI
Alzheimer’s disease disproportionately affects more women than men. And while the exact reasons for this have always been unclear, it has been suggested that this is because women tend to live longer. In the UK alone, there are approximately 500,000 women with Alzheimer’s, compared to 350,000 men. But now new research presented at an international conference suggests that differences in brain connectivity and sex-specific genes could explain why women are at greater risk of Alzheimer’s than men. Presented at the Alzheimer's Association International Conference in Los Angeles, the two separate pieces of research – one from Vanderbilt University Medical Centre and the other from the University of Miami – could lead The Vanderbilt University Medical Centre study looked at proteins called tau and amyloid in the brain, which can cause brain cells to die. It found that women’s brains had better connectivity between the regions where tau protein builds up and this can lead to faster cognitive decline. The University of Miami study found that genetics could play a part, with genes found only in women presenting a specific dementia risk. Speaking about the University of Miami research, Dr Jana Voigt, head of research at Alzheimer's Research UK, said: “We don't yet know why certain genes are linked with Alzheimer's risk in one sex and not the other - but unravelling this could provide some answers as to why more women are living with dementia than men.”
Even if you’ve been pretty physically inactive for much of your life, exercising more in your later years can still afford benefits and lower your risk of premature death, a new study has found. According to research by the University of Cambridge - which studied 15,000 Brits - by doing 150 minutes of moderate-intensity physical activity per week, physically inactive individuals can reduce their risk of early death by 24%. However, it’s people who are already physically active who can benefit the most from more exercise. That’s because the study found that individuals who were already doing 150 minutes of moderate-intensity physical activity per week could reduce their risk of early death by as much as 42%. Finally, all older adults involved in the study saw a “substantial” boost to their life expectancy by being more active – regardless of their activity levels previously. So, the simple message is clear: the more exercise, the better. And it’s never too late to make a difference in your life. Speaking about the findings of the study, the results of which are published in the British Medical Journal, Huw Edwards, from health body UKactive, said: “This provides further evidence against the outdated idea that people should do less as they age or while managing a long-term illness. “The time has come for a total rethink of how we approach our later years.”
Even though it’s widely accepted that moderate alcohol consumption can be part of a healthy lifestyle, a new study suggests that people who abstain from drinking have the highest levels of wellbeing. And it’s women who stand to benefit the most from giving up the booze. According to the study, published in the Canadian Medical Association Journal (CMAJ), men and women who have abstained from drinking alcohol their whole lives had the highest levels of mental wellbeing at the start of the 5-year study. And for females who moderately consumed alcohol (fewer than seven alcoholic drinks per week), quitting was linked with a boost in mental health. Speaking about the findings of the study, Co-author Dr Michael Ni, a brain scientist at the University of Hong Kong, said: “Global alcohol consumption is expected to continue to increase unless effective strategies are employed. Our findings suggest caution in recommendations that moderate drinking could improve health-related quality of life. “Instead, quitting drinking may be associated with a more favourable change in mental wellbeing, approaching the level of lifetime abstainers.”
A small study in the UK has found an unlikely ally in a strain of the common cold virus in the fight against bladder cancer. For the study, the findings of which appear in the journal Clinical Cancer Research, 15 patients with non-muscle invasive bladder cancer were intravenously given coxsackievirus (CVA21) ahead of scheduled surgery to remove their tumours. Post-surgery, when tissue samples were examined, there were signs the virus had targeted and killed cancer cells in the bladder. Furthermore, after the cancer cells had been killed, the virus reproduced and targeted other cancer cells. All other healthy cells were left intact. “The virus gets inside cancer cells and kills them by triggering an immune protein - and that leads to signalling of other immune cells to come and join the party,” said study leader Prof Hardev Pandha, from the University of Surrey and Royal Surrey County Hospital. The researchers from the University of Sussex who carried out the study said their findings could “help revolutionise treatment” for bladder cancer and reduce the risk of it recurring. Non-muscle invasive bladder cancer is the 10th most common cancer in the UK and affects around 10,000 new people every year. At present, treatments are either invasive, or cause toxic side effects. Moreover, constant, costly monitoring is required to ensure the cancer has not returned. Bladder cancer costs the NHS more per patient than any other cancer because of its high rate of recurrence.
A leading UK cancer charity has warned that obesity now causes more cases of four common cancers than smoking. According to Cancer Research UK, bowel, kidney, ovarian and liver cancers are more likely to be caused by being overweight than by smoking tobacco. The warning is particularly concerning as obese people outnumber smokers by two to one in the UK, which means millions of people are at risk of developing any of these cancers simply because they are overweight. Despite the fact that smoking remains the number one preventable cause of cancer in the UK and causes more cases of cancer than being overweight each year (54,300 vs. 22,800), for the four cancers previously mentioned, obesity causes more. However, Cancer Research UK’s latest billboard campaign highlighting the risks associated with being overweight has been accused of fat-shaming. And it’s not the first time the charity has been picked up for this either. Nevertheless, the charity remains adamant that outlining the risks of being overweight when it comes to cancer is an important step. Speaking about the Cancer Research UK warning, the British Medical Association said: “While we are very much aware of the health risks associated with smoking, less effort has been thrown behind tackling obesity, which is now a major cause of cancer.”