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Scientists dismantle cancer to reveal its weak spots

11/04/2019

Scientists dismantle cancer to reveal its weak spots

Scientists have dismantled cancer piece-by-piece and revealed its weaknesses in the hope that new treatments can be developed.


The team of scientists at the Wellcome Sanger Institute in Hinxton, England, disabled every genetic instruction, one at a time, inside 30 different types of cancer. Their work revealed 600 new cancer vulnerabilities, each of which could be the target of a drug.


The study is being praised in particular not only for its sheer scale, but also because it could open the doors to more personalised medicines being developed. Right now, much cancer treatment involves chemotherapy, which is far from ideal due to the damage it causes throughout a patient’s body.


One gene that was identified as being essential for the survival of some of the most genetically unstable cancers is "Werner syndrome RecQ helicase" also known more simply as WRN. It plays a vital role in around 28% of stomach cancers and 15% of colon cancers, yet there are no drugs that currently target it.


The ultimate goal is to create a “Cancer Dependency Map”, which could be used to highlight every cancer vulnerability. Medical professionals would then be able to prescribe a cocktail of precision drugs to kill a patient’s cancerous cells.


Speaking about the research, prominent UK-based cancer charity, Cancer Research UK, said that what makes the research so powerful is its sheer scale.

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