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Rainforest vine compound starves resilient pancreatic cancer cells

29/11/2018

Rainforest vine compound starves resilient pancreatic cancer cells

We recently wrote about how an exotic fish could help heal human hearts. Now, new research suggests that a rainforest vine compound is highly effective at killing treatment-resistant pancreatic cancer cells.


Known for their ability to survive even the most inhospitable conditions, pancreatic cancer cells are notoriously difficult to kill. It’s one of the reasons why pancreatic cancer is so hard to treat and why the condition usually has a poor outlook.


Indeed, the American Cancer Society (ACS) says the 5-year survival rate for pancreatic cancer patients is just 12-24 percent.


However, researchers from the Julius-Maximilians-Universität Würzburg in Germany and the Institute of Natural Medicine at the University of Toyama in Japan have discovered that a compound found in a Congolese rainforest plant can make pancreatic cancer cells susceptible to nutrient starvation.


The compound, ancistrolikokine E3, has anti-austerity properties and inhibits the Akt/mTOR pathway of pancreatic cancer cells. It’s this pathway that enables these cancer cells to thrive even under conditions of low nutrients and oxygen – an ability in the cancer field known as ‘austerity.’


While more research is needed, the compound is seen as promising for the development of future anticancer drugs.

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